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Cytomegalovirus drives Vδ1+ γδ T cell expansion and clonality in common variable immunodeficiency

Author

Listed:
  • Samantha Chan

    (Walter & Eliza Hall Institute of Medical Research
    The University of Melbourne
    Royal Melbourne Hospital
    The University of Melbourne)

  • Benjamin Morgan

    (Walter & Eliza Hall Institute of Medical Research)

  • Michelle K. Yong

    (Royal Melbourne Hospital
    The University of Melbourne
    Peter MacCallum Cancer Centre)

  • Mai Margetts

    (Walter & Eliza Hall Institute of Medical Research)

  • Anthony J. Farchione

    (Walter & Eliza Hall Institute of Medical Research
    The University of Melbourne)

  • Erin C. Lucas

    (Walter & Eliza Hall Institute of Medical Research)

  • Jack Godsell

    (Royal Melbourne Hospital
    Austin Hospital)

  • Nhi Ai Giang

    (Royal Melbourne Hospital)

  • Charlotte A. Slade

    (Walter & Eliza Hall Institute of Medical Research
    The University of Melbourne
    Royal Melbourne Hospital)

  • Anouk Borstel

    (Monash University
    Central Clinical School, Monash University)

  • Vanessa L. Bryant

    (Walter & Eliza Hall Institute of Medical Research
    The University of Melbourne
    Royal Melbourne Hospital)

  • Lauren J. Howson

    (Walter & Eliza Hall Institute of Medical Research
    The University of Melbourne)

Abstract

The function and phenotype of γδ T cells in the context of common variable immunodeficiency (CVID) has not been explored. CVID is a primary immunodeficiency disorder characterized by impaired antibody responses resulting in increased susceptibility to infections. γδ T cells are a subset of unconventional T cells that play crucial roles in host defence against infections. In this study, we aim to determine the roles and functions of γδ T cells in CVID. We observe a higher frequency of Vδ1+ γδ T cells compared to healthy controls, particularly in older patients. We also find a higher proportion of effector-memory Vδ1+ γδ T cells and a more clonal T cell receptor (TCR) repertoire in CVID. The most significant driver of the Vδ1+ γδ T cell expansion and phenotype in CVID patients is persistent cytomegalovirus (CMV) viremia. These findings provide valuable insights into γδ T cell biology and their contribution to immune defence in CVID.

Suggested Citation

  • Samantha Chan & Benjamin Morgan & Michelle K. Yong & Mai Margetts & Anthony J. Farchione & Erin C. Lucas & Jack Godsell & Nhi Ai Giang & Charlotte A. Slade & Anouk Borstel & Vanessa L. Bryant & Lauren, 2024. "Cytomegalovirus drives Vδ1+ γδ T cell expansion and clonality in common variable immunodeficiency," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-48527-3
    DOI: 10.1038/s41467-024-48527-3
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    References listed on IDEAS

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    1. Martin S. Davey & Carrie R. Willcox & Stephen P. Joyce & Kristin Ladell & Sofya A. Kasatskaya & James E. McLaren & Stuart Hunter & Mahboob Salim & Fiyaz Mohammed & David A. Price & Dmitriy M. Chudakov, 2017. "Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance," Nature Communications, Nature, vol. 8(1), pages 1-15, April.
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