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The greenbeard gene tgrB1 regulates altruism and cheating in Dictyostelium discoideum

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  • Mariko Katoh-Kurasawa

    (Baylor College of Medicine)

  • Peter Lehmann

    (Baylor College of Medicine
    Baylor College of Medicine)

  • Gad Shaulsky

    (Baylor College of Medicine)

Abstract

Greenbeard genetic elements encode rare perceptible signals, signal recognition ability, and altruism towards others that display the same signal. Putative greenbeards have been described in various organisms but direct evidence for all the properties in one system is scarce. The tgrB1-tgrC1 allorecognition system of Dictyostelium discoideum encodes two polymorphic membrane proteins which protect cells from chimerism-associated perils. During development, TgrC1 functions as a ligand-signal and TgrB1 as its receptor, but evidence for altruism has been indirect. Here, we show that mixing wild-type and activated tgrB1 cells increases wild-type spore production and relegates the mutants to the altruistic stalk, whereas mixing wild-type and tgrB1-null cells increases mutant spore production and wild-type stalk production. The tgrB1-null cells cheat only on partners that carry the same tgrC1-allotype. Therefore, TgrB1 activation confers altruism whereas TgrB1 inactivation causes allotype-specific cheating, supporting the greenbeard concept and providing insight into the relationship between allorecognition, altruism, and exploitation.

Suggested Citation

  • Mariko Katoh-Kurasawa & Peter Lehmann & Gad Shaulsky, 2024. "The greenbeard gene tgrB1 regulates altruism and cheating in Dictyostelium discoideum," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-48380-4
    DOI: 10.1038/s41467-024-48380-4
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    References listed on IDEAS

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    1. Joan E. Strassmann & Yong Zhu & David C. Queller, 2000. "Altruism and social cheating in the social amoeba Dictyostelium discoideum," Nature, Nature, vol. 408(6815), pages 965-967, December.
    2. Nicole Gruenheit & Katie Parkinson & Balint Stewart & Jennifer A. Howie & Jason B. Wolf & Christopher R. L. Thompson, 2017. "A polychromatic ‘greenbeard’ locus determines patterns of cooperation in a social amoeba," Nature Communications, Nature, vol. 8(1), pages 1-9, April.
    3. Lorenzo A. Santorelli & Christopher R. L. Thompson & Elizabeth Villegas & Jessica Svetz & Christopher Dinh & Anup Parikh & Richard Sucgang & Adam Kuspa & Joan E. Strassmann & David C. Queller & Gad Sh, 2008. "Facultative cheater mutants reveal the genetic complexity of cooperation in social amoebae," Nature, Nature, vol. 451(7182), pages 1107-1110, February.
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