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Sputum culture reversion in longer treatments with bedaquiline, delamanid, and repurposed drugs for drug-resistant tuberculosis

Author

Listed:
  • Sooyeon Kho

    (Brigham and Women’s Hospital)

  • Kwonjune J. Seung

    (Brigham and Women’s Hospital
    Partners in Health)

  • Helena Huerga

    (Epicentre)

  • Mathieu Bastard

    (Epicentre)

  • Palwasha Y. Khan

    (London School of Hygiene & Tropical Medicine
    Interactive Research and Development Global)

  • Carole D. Mitnick

    (Brigham and Women’s Hospital
    Partners in Health
    Harvard Medical School)

  • Michael L. Rich

    (Brigham and Women’s Hospital
    Partners in Health)

  • Shirajul Islam

    (Interactive Research and Development)

  • Dali Zhizhilashvili

    (Médecins sans Frontières)

  • Lusine Yeghiazaryan

    (National Center for Pulmonology)

  • Elena Nikolaevna Nikolenko

    (Republican Research and Practical Centre for Pulmonology and Tuberculosis)

  • Khin Zarli

    (Médecins sans Frontières)

  • Sana Adnan

    (Indus Hospital and Health Network)

  • Naseem Salahuddin

    (Indus Hospital and Health Network)

  • Saman Ahmed

    (Interactive Research and Development)

  • Zully Haydee Ruíz Vargas

    (Maria Auxiliadora Hospital)

  • Amsalu Bekele

    (College of Health Sciences)

  • Aiman Shaimerdenova

    (Karaganda Regional Center of Phthisiopulmonology)

  • Meseret Tamirat

    (Lesotho)

  • Alain Gelin

    (Zanmi Lasante)

  • Stalz Charles Vilbrun

    (Haitian Group for the Study of Kaposi’s Sarcoma and Opportunistic Infections (GHESKIO))

  • Catherine Hewison

    (Médecins sans Frontières)

  • Uzma Khan

    (Interactive Research and Development Global)

  • Molly Franke

    (Partners in Health
    Harvard Medical School)

Abstract

Sputum culture reversion after conversion is an indicator of tuberculosis (TB) treatment failure. We analyze data from the endTB multi-country prospective observational cohort (NCT03259269) to estimate the frequency (primary endpoint) among individuals receiving a longer (18-to-20 month) regimen for multidrug- or rifampicin-resistant (MDR/RR) TB who experienced culture conversion. We also conduct Cox proportional hazard regression analyses to identify factors associated with reversion, including comorbidities, previous treatment, cavitary disease at conversion, low body mass index (BMI) at conversion, time to conversion, and number of likely-effective drugs. Of 1,286 patients, 54 (4.2%) experienced reversion, a median of 173 days (97-306) after conversion. Cavitary disease, BMI

Suggested Citation

  • Sooyeon Kho & Kwonjune J. Seung & Helena Huerga & Mathieu Bastard & Palwasha Y. Khan & Carole D. Mitnick & Michael L. Rich & Shirajul Islam & Dali Zhizhilashvili & Lusine Yeghiazaryan & Elena Nikolaev, 2024. "Sputum culture reversion in longer treatments with bedaquiline, delamanid, and repurposed drugs for drug-resistant tuberculosis," Nature Communications, Nature, vol. 15(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-48077-8
    DOI: 10.1038/s41467-024-48077-8
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    References listed on IDEAS

    as
    1. Paul Meyvisch & Chrispin Kambili & Koen Andries & Nacer Lounis & Myriam Theeuwes & Brian Dannemann & An Vandebosch & Wim Van der Elst & Geert Molenberghs & Ariel Alonso, 2018. "Evaluation of six months sputum culture conversion as a surrogate endpoint in a multidrug resistant-tuberculosis trial," PLOS ONE, Public Library of Science, vol. 13(7), pages 1-15, July.
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