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Population pharmacokinetic modelling of primaquine exposures in lactating women and breastfed infants

Author

Listed:
  • Thanaporn Wattanakul

    (Mahidol University)

  • Mary Ellen Gilder

    (Mahidol University)

  • Rose McGready

    (Mahidol University
    Oxford University)

  • Warunee Hanpithakpong

    (Mahidol University)

  • Nicholas P. J. Day

    (Mahidol University
    Oxford University)

  • Nicholas J. White

    (Mahidol University
    Oxford University)

  • François Nosten

    (Mahidol University
    Oxford University)

  • Joel Tarning

    (Mahidol University
    Oxford University)

  • Richard M. Hoglund

    (Mahidol University
    Oxford University)

Abstract

Current guidelines advise against primaquine treatment for breastfeeding mothers to avoid the potential for haemolysis in infants with G6PD deficiency. To predict the haemolytic risk, the amount of drug received from the breast milk and the resulting infant drug exposure need to be characterised. Here, we develop a pharmacokinetic model to describe the drug concentrations in breastfeeding women using venous, capillary, and breast milk data. A mother-to-infant model is developed to mimic the infant feeding pattern and used to predict their drug exposures. Primaquine and carboxyprimaquine exposures in infants are

Suggested Citation

  • Thanaporn Wattanakul & Mary Ellen Gilder & Rose McGready & Warunee Hanpithakpong & Nicholas P. J. Day & Nicholas J. White & François Nosten & Joel Tarning & Richard M. Hoglund, 2024. "Population pharmacokinetic modelling of primaquine exposures in lactating women and breastfed infants," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47908-y
    DOI: 10.1038/s41467-024-47908-y
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