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Inflammation and mitophagy are mitochondrial checkpoints to aging

Author

Listed:
  • Emma Guilbaud

    (Weill Cornell Medicine)

  • Kristopher A. Sarosiek

    (Harvard T.H. Chan School of Public Health)

  • Lorenzo Galluzzi

    (Weill Cornell Medicine
    Sandra and Edward Meyer Cancer Center
    Caryl and Israel Englander Institute for Precision Medicine)

Abstract

Cellular and organismal aging have been consistently associated with mitochondrial dysfunction and inflammation. Accumulating evidence indicates that aging-related inflammatory responses are mechanistically linked to compromised mitochondrial integrity coupled with mtDNA-driven CGAS activation, a process that is tonically inhibited by mitophagy.

Suggested Citation

  • Emma Guilbaud & Kristopher A. Sarosiek & Lorenzo Galluzzi, 2024. "Inflammation and mitophagy are mitochondrial checkpoints to aging," Nature Communications, Nature, vol. 15(1), pages 1-3, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47840-1
    DOI: 10.1038/s41467-024-47840-1
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    References listed on IDEAS

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    1. Stella Victorelli & Hanna Salmonowicz & James Chapman & Helene Martini & Maria Grazia Vizioli & Joel S. Riley & Catherine Cloix & Ella Hall-Younger & Jair Machado Espindola-Netto & Diana Jurk & Anthon, 2023. "Apoptotic stress causes mtDNA release during senescence and drives the SASP," Nature, Nature, vol. 622(7983), pages 627-636, October.
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