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Overlapping Streptococcus pyogenes and Streptococcus dysgalactiae subspecies equisimilis household transmission and mobile genetic element exchange

Author

Listed:
  • Ouli Xie

    (University of Melbourne at the Peter Doherty Institute for Infection and Immunity
    Monash Health)

  • Cameron Zachreson

    (University of Melbourne)

  • Gerry Tonkin-Hill

    (University of Oslo)

  • David J. Price

    (University of Melbourne at the Peter Doherty Institute for Infection and Immunity
    University of Melbourne)

  • Jake A. Lacey

    (University of Melbourne at the Peter Doherty Institute for Infection and Immunity
    University of Melbourne at the Peter Doherty Institute for Infection and Immunity)

  • Jacqueline M. Morris

    (University of Melbourne at the Peter Doherty Institute for Infection and Immunity)

  • Malcolm I. McDonald

    (James Cook University)

  • Asha C. Bowen

    (University of Western Australia and Perth Children’s Hospital)

  • Philip M. Giffard

    (Charles Darwin University
    Charles Darwin University)

  • Bart J. Currie

    (Charles Darwin University
    Royal Darwin Hospital)

  • Jonathan R. Carapetis

    (University of Western Australia and Perth Children’s Hospital)

  • Deborah C. Holt

    (Charles Darwin University)

  • Stephen D. Bentley

    (Wellcome Genome Campus)

  • Mark R. Davies

    (University of Melbourne at the Peter Doherty Institute for Infection and Immunity)

  • Steven Y. C. Tong

    (University of Melbourne at the Peter Doherty Institute for Infection and Immunity
    The Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity)

Abstract

Streptococcus dysgalactiae subspecies equisimilis (SDSE) and Streptococcus pyogenes share skin and throat niches with extensive genomic homology and horizontal gene transfer (HGT) possibly underlying shared disease phenotypes. It is unknown if cross-species transmission interaction occurs. Here, we conduct a genomic analysis of a longitudinal household survey in remote Australian First Nations communities for patterns of cross-species transmission interaction and HGT. Collected from 4547 person-consultations, we analyse 294 SDSE and 315 S. pyogenes genomes. We find SDSE and S. pyogenes transmission intersects extensively among households and show that patterns of co-occurrence and transmission links are consistent with independent transmission without inter-species interference. We identify at least one of three near-identical cross-species mobile genetic elements (MGEs) carrying antimicrobial resistance or streptodornase virulence genes in 55 (19%) SDSE and 23 (7%) S. pyogenes isolates. These findings demonstrate co-circulation of both pathogens and HGT in communities with a high burden of streptococcal disease, supporting a need to integrate SDSE and S. pyogenes surveillance and control efforts.

Suggested Citation

  • Ouli Xie & Cameron Zachreson & Gerry Tonkin-Hill & David J. Price & Jake A. Lacey & Jacqueline M. Morris & Malcolm I. McDonald & Asha C. Bowen & Philip M. Giffard & Bart J. Currie & Jonathan R. Carape, 2024. "Overlapping Streptococcus pyogenes and Streptococcus dysgalactiae subspecies equisimilis household transmission and mobile genetic element exchange," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47816-1
    DOI: 10.1038/s41467-024-47816-1
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    References listed on IDEAS

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    1. Charlie Higgs & Norelle L. Sherry & Torsten Seemann & Kristy Horan & Hasini Walpola & Paul Kinsella & Katherine Bond & Deborah A. Williamson & Caroline Marshall & Jason C. Kwong & M. Lindsay Grayson &, 2022. "Optimising genomic approaches for identifying vancomycin-resistant Enterococcus faecium transmission in healthcare settings," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
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