IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-47745-z.html
   My bibliography  Save this article

Safety outcomes following COVID-19 vaccination and infection in 5.1 million children in England

Author

Listed:
  • Emma Copland

    (University of Oxford)

  • Martina Patone

    (University of Oxford)

  • Defne Saatci

    (University of Oxford)

  • Lahiru Handunnetthi

    (University of Oxford
    University of Oxford)

  • Jennifer Hirst

    (University of Oxford)

  • David P. J. Hunt

    (University of Edinburgh)

  • Nicholas L. Mills

    (University of Edinburgh
    University of Edinburgh)

  • Paul Moss

    (University of Birmingham)

  • Aziz Sheikh

    (University of Oxford
    University of Edinburgh)

  • Carol A. C. Coupland

    (University of Oxford
    University of Nottingham)

  • Anthony Harnden

    (University of Oxford)

  • Chris Robertson

    (University of Strathclyde)

  • Julia Hippisley-Cox

    (University of Oxford)

Abstract

The risk-benefit profile of COVID-19 vaccination in children remains uncertain. A self-controlled case-series study was conducted using linked data of 5.1 million children in England to compare risks of hospitalisation from vaccine safety outcomes after COVID-19 vaccination and infection. In 5-11-year-olds, we found no increased risks of adverse events 1–42 days following vaccination with BNT162b2, mRNA-1273 or ChAdOX1. In 12-17-year-olds, we estimated 3 (95%CI 0–5) and 5 (95%CI 3–6) additional cases of myocarditis per million following a first and second dose with BNT162b2, respectively. An additional 12 (95%CI 0–23) hospitalisations with epilepsy and 4 (95%CI 0–6) with demyelinating disease (in females only, mainly optic neuritis) were estimated per million following a second dose with BNT162b2. SARS-CoV-2 infection was associated with increased risks of hospitalisation from seven outcomes including multisystem inflammatory syndrome and myocarditis, but these risks were largely absent in those vaccinated prior to infection. We report a favourable safety profile of COVID-19 vaccination in under-18s.

Suggested Citation

  • Emma Copland & Martina Patone & Defne Saatci & Lahiru Handunnetthi & Jennifer Hirst & David P. J. Hunt & Nicholas L. Mills & Paul Moss & Aziz Sheikh & Carol A. C. Coupland & Anthony Harnden & Chris Ro, 2024. "Safety outcomes following COVID-19 vaccination and infection in 5.1 million children in England," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47745-z
    DOI: 10.1038/s41467-024-47745-z
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-47745-z
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-47745-z?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47745-z. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.