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Immunoglobulin G N-glycan markers of accelerated biological aging during chronic HIV infection

Author

Listed:
  • Leila B. Giron

    (The Wistar Institute)

  • Qin Liu

    (The Wistar Institute)

  • Opeyemi S. Adeniji

    (The Wistar Institute)

  • Xiangfan Yin

    (The Wistar Institute)

  • Toshitha Kannan

    (The Wistar Institute)

  • Jianyi Ding

    (The Wistar Institute)

  • David Y. Lu

    (The Wistar Institute
    Cornell University)

  • Susan Langan

    (Johns Hopkins University)

  • Jinbing Zhang

    (Johns Hopkins University)

  • Joao L. L. C. Azevedo

    (The Wistar Institute)

  • Shuk Hang Li

    (University of Pennsylvania Perelman School of Medicine)

  • Sergei Shalygin

    (University of Georgia)

  • Parastoo Azadi

    (University of Georgia)

  • David B. Hanna

    (Albert Einstein College of Medicine)

  • Igho Ofotokun

    (Emory University School of Medicine)

  • Jason Lazar

    (SUNY Downstate Health Sciences University)

  • Margaret A. Fischl

    (University of Miami)

  • Sabina Haberlen

    (Johns Hopkins University)

  • Bernard Macatangay

    (University of Pittsburgh)

  • Adaora A. Adimora

    (University of North Carolina)

  • Beth D. Jamieson

    (Los Angeles)

  • Charles Rinaldo

    (University of Pittsburgh)

  • Daniel Merenstein

    (Georgetown University Medical Center)

  • Nadia R. Roan

    (Gladstone Institutes
    University of California San Francisco)

  • Olaf Kutsch

    (University of Alabama at Birmingham)

  • Stephen Gange

    (Johns Hopkins University)

  • Steven M. Wolinsky

    (Northwestern University)

  • Mallory D. Witt

    (Lundquist Institute of Biomedical Research at Harbor-UCLA Medical Center)

  • Wendy S. Post

    (Johns Hopkins University)

  • Andrew Kossenkov

    (The Wistar Institute)

  • Alan L. Landay

    (Rush University)

  • Ian Frank

    (University of Pennsylvania Perelman School of Medicine)

  • Phyllis C. Tien

    (University of California San Francisco)

  • Robert Gross

    (University of Pennsylvania Perelman School of Medicine)

  • Todd T. Brown

    (Johns Hopkins University)

  • Mohamed Abdel-Mohsen

    (The Wistar Institute)

Abstract

People living with HIV (PLWH) experience increased vulnerability to premature aging and inflammation-associated comorbidities, even when HIV replication is suppressed by antiretroviral therapy (ART). However, the factors associated with this vulnerability remain uncertain. In the general population, alterations in the N-glycans on IgGs trigger inflammation and precede the onset of aging-associated diseases. Here, we investigate the IgG N-glycans in cross-sectional and longitudinal samples from 1214 women and men, living with and without HIV. PLWH exhibit an accelerated accumulation of pro-aging-associated glycan alterations and heightened expression of senescence-associated glycan-degrading enzymes compared to controls. These alterations correlate with elevated markers of inflammation and the severity of comorbidities, potentially preceding the development of such comorbidities. Mechanistically, HIV-specific antibodies glycoengineered with these alterations exhibit a reduced ability to elicit anti-HIV Fc-mediated immune activities. These findings hold potential for the development of biomarkers and tools to identify and prevent premature aging and comorbidities in PLWH.

Suggested Citation

  • Leila B. Giron & Qin Liu & Opeyemi S. Adeniji & Xiangfan Yin & Toshitha Kannan & Jianyi Ding & David Y. Lu & Susan Langan & Jinbing Zhang & Joao L. L. C. Azevedo & Shuk Hang Li & Sergei Shalygin & Par, 2024. "Immunoglobulin G N-glycan markers of accelerated biological aging during chronic HIV infection," Nature Communications, Nature, vol. 15(1), pages 1-23, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47279-4
    DOI: 10.1038/s41467-024-47279-4
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    References listed on IDEAS

    as
    1. Rifqah Abeeda Roomaney & Brian van Wyk & Victoria Pillay-van Wyk, 2022. "Aging with HIV: Increased Risk of HIV Comorbidities in Older Adults," IJERPH, MDPI, vol. 19(4), pages 1-10, February.
    2. Silvestre, A.J. & Hylton, J.B. & Johnson, L.M. & Houston, C. & Witt, M. & Jacobson, L. & Ostrow, D., 2006. "Recruiting minority men who have sex with men for HIV research: Results from a 4-city campaign," American Journal of Public Health, American Public Health Association, vol. 96(6), pages 1020-1027.
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