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Concomitant medication, comorbidity and survival in patients with breast cancer

Author

Listed:
  • Elise Dumas

    (Université Paris Cité
    U900
    CBIO-Centre for Computational Biology)

  • Beatriz Grandal Rejo

    (Université Paris Cité)

  • Paul Gougis

    (Université Paris Cité)

  • Sophie Houzard

    (Health Survey Data Science and Assessment Division, French National Cancer Institute (Institut National du Cancer INCa))

  • Judith Abécassis

    (Université Paris Cité
    Paris-Saclay University, CEA)

  • Floriane Jochum

    (Université Paris Cité
    Strasbourg University Hospital)

  • Benjamin Marande

    (Université Paris Cité)

  • Annabelle Ballesta

    (PSL Research University)

  • Elaine Nery

    (PICT-IBISA, PSL Research University)

  • Thierry Dubois

    (Institut Curie - PSL Research University Translational Research Department Breast Cancer Biology Group 26 rue d’Ulm)

  • Samar Alsafadi

    (PSL Research University, Uveal Melanoma Group, Translational Research Department)

  • Bernard Asselain

    (Unicancer)

  • Aurélien Latouche

    (U900
    PSL Research University
    Conservatoire National des Arts et Métiers)

  • Marc Espie

    (Université Paris Cité)

  • Enora Laas

    (Université Paris Cité, Institut Curie)

  • Florence Coussy

    (Université Paris Cité, Institut Curie)

  • Clémentine Bouchez

    (Université Paris Cité)

  • Jean-Yves Pierga

    (Université Paris Cité, Institut Curie)

  • Christine Bihan-Benjamin

    (Health Survey Data Science and Assessment Division, French National Cancer Institute (Institut National du Cancer INCa))

  • Philippe-Jean Bousquet

    (Équipe Labellisée Ligue Contre le Cancer
    French National Cancer Institute (Institut National du Cancer INCa))

  • Judicaël Hotton

    (Institut Jean Godinot)

  • Chloé-Agathe Azencott

    (U900
    CBIO-Centre for Computational Biology
    PSL Research University)

  • Fabien Reyal

    (Université Paris Cité
    Université Paris Cité, Institut Curie
    Institut Jean Godinot)

  • Anne-Sophie Hamy

    (Université Paris Cité
    Université Paris Cité, Institut Curie)

Abstract

Between 30% and 70% of patients with breast cancer have pre-existing chronic conditions, and more than half are on long-term non-cancer medication at the time of diagnosis. Preliminary epidemiological evidence suggests that some non-cancer medications may affect breast cancer risk, recurrence, and survival. In this nationwide cohort study, we assessed the association between medication use at breast cancer diagnosis and survival. We included 235,368 French women with newly diagnosed non-metastatic breast cancer. In analyzes of 288 medications, we identified eight medications positively associated with either overall survival or disease-free survival: rabeprazole, alverine, atenolol, simvastatin, rosuvastatin, estriol (vaginal or transmucosal), nomegestrol, and hypromellose; and eight medications negatively associated with overall survival or disease-free survival: ferrous fumarate, prednisolone, carbimazole, pristinamycin, oxazepam, alprazolam, hydroxyzine, and mianserin. Full results are available online from an interactive platform ( https://adrenaline.curie.fr ). This resource provides hypotheses for drugs that may naturally influence breast cancer evolution.

Suggested Citation

  • Elise Dumas & Beatriz Grandal Rejo & Paul Gougis & Sophie Houzard & Judith Abécassis & Floriane Jochum & Benjamin Marande & Annabelle Ballesta & Elaine Nery & Thierry Dubois & Samar Alsafadi & Bernard, 2024. "Concomitant medication, comorbidity and survival in patients with breast cancer," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47002-3
    DOI: 10.1038/s41467-024-47002-3
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    References listed on IDEAS

    as
    1. Xi-Ping Huang & Joel Karpiak & Wesley K. Kroeze & Hu Zhu & Xin Chen & Sheryl S. Moy & Kara A. Saddoris & Viktoriya D. Nikolova & Martilias S. Farrell & Sheng Wang & Thomas J. Mangano & Deepak A. Deshp, 2015. "Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65," Nature, Nature, vol. 527(7579), pages 477-483, November.
    2. Phyu Sin Aye & Oliver W. Scott & J. Mark Elwood & Diana Sarfati & Ross Lawrenson & Ian D. Campbell & Marion Kuper-Hommel & Sandar Tin Tin, 2020. "Use of Non-Cancer Medications in New Zealand Women at the Diagnosis of Primary Invasive Breast Cancer: Prevalence, Associated Factors and Effects on Survival," IJERPH, MDPI, vol. 17(21), pages 1-12, October.
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