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Elevated blood remnant cholesterol and triglycerides are causally related to the risks of cardiometabolic multimorbidity

Author

Listed:
  • Yimin Zhao

    (Peking University Third Hospital, Peking University
    Peking University)

  • Zhenhuang Zhuang

    (Peking University)

  • Yueying Li

    (Peking University)

  • Wendi Xiao

    (Peking University)

  • Zimin Song

    (Peking University)

  • Ninghao Huang

    (Peking University)

  • Wenxiu Wang

    (Peking University)

  • Xue Dong

    (Peking University)

  • Jinzhu Jia

    (Peking University)

  • Robert Clarke

    (University of Oxford)

  • Tao Huang

    (Peking University
    Ministry of Education
    Peking University)

Abstract

The connection between triglyceride-rich lipoproteins and cardiometabolic multimorbidity, characterized by the concurrence of at least two of type 2 diabetes, ischemic heart disease, and stroke, has not been definitively established. We aim to examine the prospective associations between serum remnant cholesterol, triglycerides, and the risks of progression from first cardiometabolic disease to multimorbidity via multistate modeling in the UK Biobank. We also evaluate the causality of these associations via Mendelian randomization using 13 biologically relevant SNPs as the genetic instruments. Here we show that elevated remnant cholesterol and triglycerides are significantly associated with gradually higher risks of cardiometabolic multimorbidity, particularly the progression of ischemic heart disease to the multimorbidity of ischemic heart disease and type 2 diabetes. These results advocate for effective management of remnant cholesterol and triglycerides as a potential strategy in mitigating the risks of cardiometabolic multimorbidity.

Suggested Citation

  • Yimin Zhao & Zhenhuang Zhuang & Yueying Li & Wendi Xiao & Zimin Song & Ninghao Huang & Wenxiu Wang & Xue Dong & Jinzhu Jia & Robert Clarke & Tao Huang, 2024. "Elevated blood remnant cholesterol and triglycerides are causally related to the risks of cardiometabolic multimorbidity," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46686-x
    DOI: 10.1038/s41467-024-46686-x
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