Therapeutic targeting nudix hydrolase 1 creates a MYC-driven metabolic vulnerability
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DOI: 10.1038/s41467-024-46572-6
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- Helge Gad & Tobias Koolmeister & Ann-Sofie Jemth & Saeed Eshtad & Sylvain A. Jacques & Cecilia E. Ström & Linda M. Svensson & Niklas Schultz & Thomas Lundbäck & Berglind Osk Einarsdottir & Aljona Sale, 2014. "MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool," Nature, Nature, vol. 508(7495), pages 215-221, April.
- Liyuan Wang & Chan Chen & Zemin Song & Honghong Wang & Minghui Ye & Donghai Wang & Wenqian Kang & Hudan Liu & Guoliang Qing, 2022. "EZH2 depletion potentiates MYC degradation inhibiting neuroblastoma and small cell carcinoma tumor formation," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
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