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Neuropathogenesis-on-chips for neurodegenerative diseases

Author

Listed:
  • Sarnai Amartumur

    (Sungkyunkwan University)

  • Huong Nguyen

    (Sungkyunkwan University)

  • Thuy Huynh

    (Sungkyunkwan University)

  • Testaverde S. Kim

    (Institute for Basic Science (IBS))

  • Ran-Sook Woo

    (Eulji University)

  • Eungseok Oh

    (Chungnam National University Hospital)

  • Kyeong Kyu Kim

    (Sungkyunkwan University School of Medicine)

  • Luke P. Lee

    (Sungkyunkwan University
    Brigham and Women’s Hospital
    University of California)

  • Chaejeong Heo

    (Sungkyunkwan University
    Institute for Basic Science (IBS))

Abstract

Developing diagnostics and treatments for neurodegenerative diseases (NDs) is challenging due to multifactorial pathogenesis that progresses gradually. Advanced in vitro systems that recapitulate patient-like pathophysiology are emerging as alternatives to conventional animal-based models. In this review, we explore the interconnected pathogenic features of different types of ND, discuss the general strategy to modelling NDs using a microfluidic chip, and introduce the organoid-on-a-chip as the next advanced relevant model. Lastly, we overview how these models are being applied in academic and industrial drug development. The integration of microfluidic chips, stem cells, and biotechnological devices promises to provide valuable insights for biomedical research and developing diagnostic and therapeutic solutions for NDs.

Suggested Citation

  • Sarnai Amartumur & Huong Nguyen & Thuy Huynh & Testaverde S. Kim & Ran-Sook Woo & Eungseok Oh & Kyeong Kyu Kim & Luke P. Lee & Chaejeong Heo, 2024. "Neuropathogenesis-on-chips for neurodegenerative diseases," Nature Communications, Nature, vol. 15(1), pages 1-34, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46554-8
    DOI: 10.1038/s41467-024-46554-8
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