IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-46431-4.html
   My bibliography  Save this article

Tissue engineered vascular grafts are resistant to the formation of dystrophic calcification

Author

Listed:
  • Mackenzie E. Turner

    (Research Institute at Nationwide Children’s Hospital
    The Ohio State University)

  • Kevin M. Blum

    (Research Institute at Nationwide Children’s Hospital
    The Ohio State University College of Medicine)

  • Tatsuya Watanabe

    (Research Institute at Nationwide Children’s Hospital)

  • Erica L. Schwarz

    (Yale University)

  • Mahboubeh Nabavinia

    (Research Institute at Nationwide Children’s Hospital)

  • Joseph T. Leland

    (Research Institute at Nationwide Children’s Hospital)

  • Delaney J. Villarreal

    (Research Institute at Nationwide Children’s Hospital
    The Ohio State University College of Medicine
    The Ohio State University College of Medicine)

  • William E. Schwartzman

    (Research Institute at Nationwide Children’s Hospital
    The Ohio State University College of Medicine)

  • Ting-Heng Chou

    (Research Institute at Nationwide Children’s Hospital
    National Taipei University of Nursing and Health Sciences)

  • Peter B. Baker

    (Pathology Department at Nationwide Children’s Hospital and The Ohio State University)

  • Goki Matsumura

    (Tokyo Women’s Medical University)

  • Rajesh Krishnamurthy

    (Nationwide Children’s Hospital and The Ohio State University)

  • Andrew R. Yates

    (The Ohio State University College of Medicine
    Nationwide Children’s Hospital)

  • Kan N. Hor

    (The Ohio State University College of Medicine
    Nationwide Children’s Hospital)

  • Jay D. Humphrey

    (Yale University)

  • Alison L. Marsden

    (Stanford University)

  • Mitchel R. Stacy

    (Research Institute at Nationwide Children’s Hospital
    The Ohio State University College of Medicine
    The Ohio State University)

  • Toshiharu Shinoka

    (Research Institute at Nationwide Children’s Hospital
    Nationwide Children’s Hospital
    Nationwide Children’s Hospital)

  • Christopher K. Breuer

    (Research Institute at Nationwide Children’s Hospital
    The Ohio State University College of Medicine
    Nationwide Children’s Hospital)

Abstract

Advancements in congenital heart surgery have heightened the importance of durable biomaterials for adult survivors. Dystrophic calcification poses a significant risk to the long-term viability of prosthetic biomaterials in these procedures. Herein, we describe the natural history of calcification in the most frequently used vascular conduits, expanded polytetrafluoroethylene grafts. Through a retrospective clinical study and an ovine model, we compare the degree of calcification between tissue-engineered vascular grafts and polytetrafluoroethylene grafts. Results indicate superior durability in tissue-engineered vascular grafts, displaying reduced late-term calcification in both clinical studies (p

Suggested Citation

  • Mackenzie E. Turner & Kevin M. Blum & Tatsuya Watanabe & Erica L. Schwarz & Mahboubeh Nabavinia & Joseph T. Leland & Delaney J. Villarreal & William E. Schwartzman & Ting-Heng Chou & Peter B. Baker & , 2024. "Tissue engineered vascular grafts are resistant to the formation of dystrophic calcification," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46431-4
    DOI: 10.1038/s41467-024-46431-4
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-46431-4
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-46431-4?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46431-4. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.