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A wireless battery-free eye modulation patch for high myopia therapy

Author

Listed:
  • Tianyan Zhong

    (University of Electronic Science and Technology of China)

  • Hangjin Yi

    (University of Electronic Science and Technology of China
    Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China)

  • Jiacheng Gou

    (University of Electronic Science and Technology of China)

  • Jie Li

    (Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China)

  • Miao Liu

    (Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China)

  • Xing Gao

    (Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China)

  • Sizhu Chen

    (Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China)

  • Hongye Guan

    (University of Electronic Science and Technology of China)

  • Shan Liang

    (University of Electronic Science and Technology of China)

  • Qianxiong He

    (University of Electronic Science and Technology of China)

  • Rui Lin

    (University of Electronic Science and Technology of China)

  • Zhihe Long

    (City University of Hong Kong)

  • Yue Wang

    (University of Electronic Science and Technology of China)

  • Chuang Shi

    (University of Electronic Science and Technology of China)

  • Yang Zhan

    (Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences)

  • Yan Zhang

    (University of Electronic Science and Technology of China)

  • Lili Xing

    (University of Electronic Science and Technology of China)

  • Jie Zhong

    (University of Electronic Science and Technology of China
    Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China)

  • Xinyu Xue

    (University of Electronic Science and Technology of China)

Abstract

The proper axial length of the eye is crucial for achieving emmetropia. In this study, we present a wireless battery-free eye modulation patch designed to correct high myopia and prevent relapse. The patch consists of piezoelectric transducers, an electrochemical micro-actuator, a drug microneedle array, μ-LEDs, a flexible circuit, and biocompatible encapsulation. The system can be wirelessly powered and controlled using external ultrasound. The electrochemical micro-actuator plays a key role in precisely shortening the axial length by driving the posterior sclera inward. This ensures accurate scene imaging on the retina for myopia eye. The drug microneedle array delivers riboflavin to the posterior sclera, and μ-LEDs’ blue light induces collagen cross-linking, reinforcing sclera strength. In vivo experiments demonstrate that the patch successfully reduces the rabbit eye’s axial length by ~1217 μm and increases sclera strength by 387%. The system operates effectively within the body without the need for batteries. Here, we show that the patch offers a promising avenue for clinically treating high myopia.

Suggested Citation

  • Tianyan Zhong & Hangjin Yi & Jiacheng Gou & Jie Li & Miao Liu & Xing Gao & Sizhu Chen & Hongye Guan & Shan Liang & Qianxiong He & Rui Lin & Zhihe Long & Yue Wang & Chuang Shi & Yang Zhan & Yan Zhang &, 2024. "A wireless battery-free eye modulation patch for high myopia therapy," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46049-6
    DOI: 10.1038/s41467-024-46049-6
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    References listed on IDEAS

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    1. Graham E. Quinn & Chai H. Shin & Maureen G. Maguire & Richard A. Stone, 1999. "Myopia and ambient lighting at night," Nature, Nature, vol. 399(6732), pages 113-114, May.
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