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Annexins—a family of proteins with distinctive tastes for cell signaling and membrane dynamics

Author

Listed:
  • Volker Gerke

    (University of Münster)

  • Felicity N. E. Gavins

    (Brunel University London)

  • Michael Geisow

    (The National Institute for Medical Research, Mill Hill
    Delta Biotechnology Ltd)

  • Thomas Grewal

    (University of Sydney)

  • Jyoti K. Jaiswal

    (Children’s National Research and Innovation Campus
    The George Washington University School of Medicine and Health Sciences)

  • Jesper Nylandsted

    (Danish Cancer Institute
    University of Southern Denmark)

  • Ursula Rescher

    (University of Münster)

Abstract

Annexins are cytosolic proteins with conserved three-dimensional structures that bind acidic phospholipids in cellular membranes at elevated Ca2+ levels. Through this they act as Ca2+-regulated membrane binding modules that organize membrane lipids, facilitating cellular membrane transport but also displaying extracellular activities. Recent discoveries highlight annexins as sensors and regulators of cellular and organismal stress, controlling inflammatory reactions in mammals, environmental stress in plants, and cellular responses to plasma membrane rupture. Here, we describe the role of annexins as Ca2+-regulated membrane binding modules that sense and respond to cellular stress and share our view on future research directions in the field.

Suggested Citation

  • Volker Gerke & Felicity N. E. Gavins & Michael Geisow & Thomas Grewal & Jyoti K. Jaiswal & Jesper Nylandsted & Ursula Rescher, 2024. "Annexins—a family of proteins with distinctive tastes for cell signaling and membrane dynamics," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45954-0
    DOI: 10.1038/s41467-024-45954-0
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    References listed on IDEAS

    as
    1. Maria Fankhaenel & Farahnaz S. Golestan Hashemi & Larissa Mourao & Emily Lucas & Manal M. Hosawi & Paul Skipp & Xavier Morin & Colinda L.G.J. Scheele & Salah Elias, 2023. "Annexin A1 is a polarity cue that directs mitotic spindle orientation during mammalian epithelial morphogenesis," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
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