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4D printed hydrogel scaffold with swelling-stiffening properties and programmable deformation for minimally invasive implantation

Author

Listed:
  • Bo Liu

    (Chinese Academy of Sciences
    Hebei University of Technology)

  • Hui Li

    (Chinese Academy of Sciences)

  • Fengzhen Meng

    (Chinese Academy of Sciences)

  • Ziyang Xu

    (Tianjin University)

  • Liuzhi Hao

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Yuan Yao

    (Tianjin University)

  • Hao Zhu

    (Chinese Academy of Sciences)

  • Chenmin Wang

    (Chinese Academy of Sciences)

  • Jun Wu

    (The University of Hong Kong-Shenzhen Hospital)

  • Shaoquan Bian

    (Chinese Academy of Sciences)

  • Willima W. Lu

    (Chinese Academy of Sciences
    The University of Hong Kong)

  • Wenguang Liu

    (Tianjin University)

  • Haobo Pan

    (Chinese Academy of Sciences)

  • Xiaoli Zhao

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

Abstract

The power of three-dimensional printing in designing personalized scaffolds with precise dimensions and properties is well-known. However, minimally invasive implantation of complex scaffolds is still challenging. Here, we develop amphiphilic dynamic thermoset polyurethanes catering for multi-material four-dimensional printing to fabricate supportive scaffolds with body temperature-triggered shape memory and water-triggered programmable deformation. Shape memory effect enables the two-dimensional printed pattern to be fixed into temporary one-dimensional shape, facilitating transcatheter delivery. Upon implantation, the body temperature triggers shape recovery of the one-dimensional shape to its original two-dimensional pattern. After swelling, the hydrated pattern undergoes programmable morphing into the desired three-dimensional structure because of swelling mismatch. The structure exhibits unusual soft-to-stiff transition due to the water-driven microphase separation formed between hydrophilic and hydrophobic chain segments. The integration of shape memory, programmable deformability, and swelling-stiffening properties makes the developed dynamic thermoset polyurethanes promising supportive void-filling scaffold materials for minimally invasive implantation.

Suggested Citation

  • Bo Liu & Hui Li & Fengzhen Meng & Ziyang Xu & Liuzhi Hao & Yuan Yao & Hao Zhu & Chenmin Wang & Jun Wu & Shaoquan Bian & Willima W. Lu & Wenguang Liu & Haobo Pan & Xiaoli Zhao, 2024. "4D printed hydrogel scaffold with swelling-stiffening properties and programmable deformation for minimally invasive implantation," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45938-0
    DOI: 10.1038/s41467-024-45938-0
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    References listed on IDEAS

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    1. Andrew C. Weems & Maria C. Arno & Wei Yu & Robert T. R. Huckstepp & Andrew P. Dove, 2021. "4D polycarbonates via stereolithography as scaffolds for soft tissue repair," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
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