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Global evaluation of lineage-specific human papillomavirus capsid antigenicity using antibodies elicited by natural infection

Author

Listed:
  • Gathoni Kamuyu

    (UK Health Security Agency)

  • Filomeno Coelho da Silva

    (UK Health Security Agency)

  • Vanessa Tenet

    (Prevention and Infections Branch)

  • John Schussler

    (Information Management Services Inc)

  • Anna Godi

    (UK Health Security Agency)

  • Rolando Herrero

    (Fundación INCIENSA (FUNIN))

  • Carolina Porras

    (Fundación INCIENSA (FUNIN))

  • Lisa Mirabello

    (National Cancer Institute)

  • John T. Schiller

    (National Cancer Institute)

  • Mónica S. Sierra

    (National Cancer Institute)

  • Aimée R. Kreimer

    (National Cancer Institute)

  • Gary M. Clifford

    (Prevention and Infections Branch)

  • Simon Beddows

    (UK Health Security Agency
    UK Health Security Agency)

Abstract

Human Papillomavirus (HPV) type variants have been classified into lineages and sublineages based upon their whole genome sequence. Here we have examined the specificity of antibodies generated following natural infection with lineage variants of oncogenic types (HPV16, 18, 31, 33, 45, 52 and 58) by testing serum samples assembled from existing archives from women residing in Africa, The Americas, Asia or Europe against representative lineage-specific pseudoviruses for each genotype. We have subjected the resulting neutralizing antibody data to antigenic clustering methods and created relational antigenic profiles for each genotype to inform the delineation of lineage-specific serotypes. For most genotypes, there was evidence of differential recognition of lineage-specific antigens and in some cases of a sufficient magnitude to suggest that some lineages should be considered antigenically distinct within their respective genotypes. These data provide compelling evidence for a degree of lineage specificity within the humoral immune response following natural infection with oncogenic HPV.

Suggested Citation

  • Gathoni Kamuyu & Filomeno Coelho da Silva & Vanessa Tenet & John Schussler & Anna Godi & Rolando Herrero & Carolina Porras & Lisa Mirabello & John T. Schiller & Mónica S. Sierra & Aimée R. Kreimer & G, 2024. "Global evaluation of lineage-specific human papillomavirus capsid antigenicity using antibodies elicited by natural infection," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45807-w
    DOI: 10.1038/s41467-024-45807-w
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