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Genomic epidemiology reveals geographical clustering of multidrug-resistant Escherichia coli ST131 associated with bacteraemia in Wales

Author

Listed:
  • Rhys T. White

    (The University of Queensland
    The University of Queensland
    The University of Queensland
    Institute of Environmental Science and Research)

  • Matthew J. Bull

    (Cardiff University
    University Hospital of Wales)

  • Clare R. Barker

    (Cardiff University)

  • Julie M. Arnott

    (Public Health Wales, 2 Capital Quarter)

  • Mandy Wootton

    (University Hospital of Wales)

  • Lim S. Jones

    (University Hospital of Wales)

  • Robin A. Howe

    (University Hospital of Wales)

  • Mari Morgan

    (Public Health Wales, 2 Capital Quarter)

  • Melinda M. Ashcroft

    (The University of Melbourne at The Peter Doherty Institute for Infection and Immunity)

  • Brian M. Forde

    (The University of Queensland
    Royal Brisbane & Women’s Hospital Campus)

  • Thomas R. Connor

    (Cardiff University
    Public Health Wales, 2 Capital Quarter)

  • Scott A. Beatson

    (The University of Queensland
    The University of Queensland
    The University of Queensland)

Abstract

Antibiotic resistance is a significant global public health concern. Uropathogenic Escherichia coli sequence type (ST)131, a widely prevalent multidrug-resistant clone, is frequently associated with bacteraemia. This study investigates third-generation cephalosporin resistance in bloodstream infections caused by E. coli ST131. From 2013-2014 blood culture surveillance in Wales, 142 E. coli ST131 genomes were studied alongside global data. All three major ST131 clades were represented across Wales, with clade C/H30 predominant (n = 102/142, 71.8%). Consistent with global findings, Welsh strains of clade C/H30 contain β-lactamase genes from the blaCTX-M-1 group (n = 65/102, 63.7%), which confer resistance to third-generation cephalosporins. Most Welsh clade C/H30 genomes belonged to sub-clade C2/H30Rx (58.3%). A Wales-specific sub-lineage, named GB-WLS.C2, diverged around 1996-2000. An introduction to North Wales around 2002 led to a localised cluster by 2009, depicting limited genomic diversity within North Wales. This investigation emphasises the value of genomic epidemiology, allowing the detection of genetically similar strains in local areas, enabling targeted and timely public health interventions.

Suggested Citation

  • Rhys T. White & Matthew J. Bull & Clare R. Barker & Julie M. Arnott & Mandy Wootton & Lim S. Jones & Robin A. Howe & Mari Morgan & Melinda M. Ashcroft & Brian M. Forde & Thomas R. Connor & Scott A. Be, 2024. "Genomic epidemiology reveals geographical clustering of multidrug-resistant Escherichia coli ST131 associated with bacteraemia in Wales," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45608-1
    DOI: 10.1038/s41467-024-45608-1
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    References listed on IDEAS

    as
    1. Brian M. Forde & Leah W. Roberts & Minh-Duy Phan & Kate M. Peters & Brittany A. Fleming & Colin W. Russell & Sara M. Lenherr & Jeremy B. Myers & Adam P. Barker & Mark A. Fisher & Teik-Min Chong & Wai-, 2019. "Population dynamics of an Escherichia coli ST131 lineage during recurrent urinary tract infection," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
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