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Malnutrition enteropathy in Zambian and Zimbabwean children with severe acute malnutrition: A multi-arm randomized phase II trial

Author

Listed:
  • Kanta Chandwe

    (University of Zambia School of Medicine)

  • Mutsa Bwakura-Dangarembizi

    (Zvitambo Institute for Maternal and Child Health Research
    University of Zimbabwe, Parirenyatwa Hospital)

  • Beatrice Amadi

    (University of Zambia School of Medicine)

  • Gertrude Tawodzera

    (Zvitambo Institute for Maternal and Child Health Research)

  • Deophine Ngosa

    (University of Zambia School of Medicine)

  • Anesu Dzikiti

    (Zvitambo Institute for Maternal and Child Health Research)

  • Nivea Chulu

    (University of Zambia School of Medicine)

  • Robert Makuyana

    (Zvitambo Institute for Maternal and Child Health Research)

  • Kanekwa Zyambo

    (University of Zambia School of Medicine)

  • Kuda Mutasa

    (Zvitambo Institute for Maternal and Child Health Research)

  • Chola Mulenga

    (University of Zambia School of Medicine)

  • Ellen Besa

    (University of Zambia School of Medicine)

  • Jonathan P. Sturgeon

    (Zvitambo Institute for Maternal and Child Health Research
    Queen Mary University of London)

  • Shepherd Mudzingwa

    (Zvitambo Institute for Maternal and Child Health Research)

  • Bwalya Simunyola

    (University of Zambia School of Medicine)

  • Lydia Kazhila

    (University of Zambia School of Medicine)

  • Masuzyo Zyambo

    (University of Zambia School of Medicine)

  • Hazel Sonkwe

    (University of Zambia School of Medicine)

  • Batsirai Mutasa

    (Zvitambo Institute for Maternal and Child Health Research)

  • Miyoba Chipunza

    (University of Zambia School of Medicine)

  • Virginia Sauramba

    (Zvitambo Institute for Maternal and Child Health Research)

  • Lisa Langhaug

    (Zvitambo Institute for Maternal and Child Health Research)

  • Victor Mudenda

    (University of Zambia School of Medicine)

  • Simon H. Murch

    (Warwick University Medical School)

  • Susan Hill

    (Great Ormond Street Hospital)

  • Raymond J. Playford

    (University of West London
    University College Cork)

  • Kelley VanBuskirk

    (University of Zambia School of Medicine)

  • Andrew J. Prendergast

    (Zvitambo Institute for Maternal and Child Health Research
    Queen Mary University of London)

  • Paul Kelly

    (University of Zambia School of Medicine
    Queen Mary University of London)

Abstract

Malnutrition underlies almost half of all child deaths globally. Severe Acute Malnutrition (SAM) carries unacceptable mortality, particularly if accompanied by infection or medical complications, including enteropathy. We evaluated four interventions for malnutrition enteropathy in a multi-centre phase II multi-arm trial in Zambia and Zimbabwe and completed in 2021. The purpose of this trial was to identify therapies which could be taken forward into phase III trials. Children of either sex were eligible for inclusion if aged 6–59 months and hospitalised with SAM (using WHO definitions: WLZ

Suggested Citation

  • Kanta Chandwe & Mutsa Bwakura-Dangarembizi & Beatrice Amadi & Gertrude Tawodzera & Deophine Ngosa & Anesu Dzikiti & Nivea Chulu & Robert Makuyana & Kanekwa Zyambo & Kuda Mutasa & Chola Mulenga & Ellen, 2024. "Malnutrition enteropathy in Zambian and Zimbabwean children with severe acute malnutrition: A multi-arm randomized phase II trial," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45528-0
    DOI: 10.1038/s41467-024-45528-0
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