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Shape-recovery of implanted shape-memory devices remotely triggered via image-guided ultrasound heating

Author

Listed:
  • Yang Zhu

    (Zhejiang University
    University of Pittsburgh
    University of Pittsburgh
    Binjiang Institute of Zhejiang University)

  • Kaicheng Deng

    (Zhejiang University)

  • Jianwei Zhou

    (NingboTech University)

  • Chong Lai

    (Zhejiang University)

  • Zuwei Ma

    (University of Pittsburgh)

  • Hua Zhang

    (Zhejiang University)

  • Jiazhen Pan

    (Zhejiang University)

  • Liyin Shen

    (Zhejiang University)

  • Matthew D. Bucknor

    (University of California)

  • Eugene Ozhinsky

    (University of California)

  • Seungil Kim

    (University of Pittsburgh
    University of Pittsburgh)

  • Guangjie Chen

    (Zhejiang University)

  • Sang-ho Ye

    (University of Pittsburgh
    University of Pittsburgh)

  • Yue Zhang

    (University of California)

  • Donghong Liu

    (Zhejiang University)

  • Changyou Gao

    (Zhejiang University)

  • Yonghua Xu

    (Department of Imaging and Interventional Radiology, Zhongshan-Xuhui Hospital of Fudan University/Shanghai Xuhui Central Hospital)

  • Huanan Wang

    (Zhejiang University)

  • William R. Wagner

    (University of Pittsburgh
    University of Pittsburgh
    University of Pittsburgh
    University of Pittsburgh)

Abstract

Shape-memory materials hold great potential to impart medical devices with functionalities useful during implantation, locomotion, drug delivery, and removal. However, their clinical translation is limited by a lack of non-invasive and precise methods to trigger and control the shape recovery, especially for devices implanted in deep tissues. In this study, the application of image-guided high-intensity focused ultrasound (HIFU) heating is tested. Magnetic resonance-guided HIFU triggered shape-recovery of a device made of polyurethane urea while monitoring its temperature by magnetic resonance thermometry. Deformation of the polyurethane urea in a live canine bladder (5 cm deep) is achieved with 8 seconds of ultrasound-guided HIFU with millimeter resolution energy focus. Tissue sections show no hyperthermic tissue injury. A conceptual application in ureteral stent shape-recovery reduces removal resistance. In conclusion, image-guided HIFU demonstrates deep energy penetration, safety and speed.

Suggested Citation

  • Yang Zhu & Kaicheng Deng & Jianwei Zhou & Chong Lai & Zuwei Ma & Hua Zhang & Jiazhen Pan & Liyin Shen & Matthew D. Bucknor & Eugene Ozhinsky & Seungil Kim & Guangjie Chen & Sang-ho Ye & Yue Zhang & Do, 2024. "Shape-recovery of implanted shape-memory devices remotely triggered via image-guided ultrasound heating," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45437-2
    DOI: 10.1038/s41467-024-45437-2
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