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Two way workable microchanneled hydrogel suture to diagnose, treat and monitor the infarcted heart

Author

Listed:
  • Fangchao Xue

    (Third Military Medical University)

  • Shanlan Zhao

    (Third Military Medical University)

  • Hao Tian

    (Third Military Medical University)

  • Haoxiang Qin

    (Third Military Medical University)

  • Xiaochen Li

    (Third Military Medical University)

  • Zhao Jian

    (Third Military Medical University)

  • Jiahui Du

    (Third Military Medical University)

  • Yanzhao Li

    (Third Military Medical University)

  • Yanhong Wang

    (Third Military Medical University)

  • Lin Lin

    (Third Military Medical University)

  • Chen Liu

    (Third Military Medical University)

  • Yongning Shang

    (Third Military Medical University)

  • Lang He

    (Third Military Medical University)

  • Malcolm Xing

    (Department of Mechanical Engineering University of Manitoba)

  • Wen Zeng

    (Third Military Medical University
    State Key Laboratory of Trauma and Chemical Poisoning
    Jinfeng Laboratory)

Abstract

During myocardial infarction, microcirculation disturbance in the ischemic area can cause necrosis and formation of fibrotic tissue, potentially leading to malignant arrhythmia and myocardial remodeling. Here, we report a microchanneled hydrogel suture for two-way signal communication, pumping drugs on demand, and cardiac repair. After myocardial infarction, our hydrogel suture monitors abnormal electrocardiogram through the mobile device and triggers nitric oxide on demand via the hydrogel sutures’ microchannels, thereby inhibiting inflammation, promoting microvascular remodeling, and improving the left ventricular ejection fraction in rats and minipigs by more than 60% and 50%, respectively. This work proposes a suture for bidirectional communication that acts as a cardio-patch to repair myocardial infarction, that remotely monitors the heart, and can deliver drugs on demand.

Suggested Citation

  • Fangchao Xue & Shanlan Zhao & Hao Tian & Haoxiang Qin & Xiaochen Li & Zhao Jian & Jiahui Du & Yanzhao Li & Yanhong Wang & Lin Lin & Chen Liu & Yongning Shang & Lang He & Malcolm Xing & Wen Zeng, 2024. "Two way workable microchanneled hydrogel suture to diagnose, treat and monitor the infarcted heart," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45144-y
    DOI: 10.1038/s41467-024-45144-y
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