IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-44963-3.html
   My bibliography  Save this article

Redox-responsive polymer micelles co-encapsulating immune checkpoint inhibitors and chemotherapeutic agents for glioblastoma therapy

Author

Listed:
  • Zhiqi Zhang

    (Southeast University)

  • Xiaoxuan Xu

    (Southeast University)

  • Jiawei Du

    (Southeast University)

  • Xin Chen

    (Southeast University)

  • Yonger Xue

    (Shanghai Jiao Tong University)

  • Jianqiong Zhang

    (Southeast University
    Southeast University)

  • Xue Yang

    (Southeast University)

  • Xiaoyuan Chen

    (National University of Singapore
    National University of Singapore
    National University of Singapore
    Institute of Molecular and Cell Biology, Agency for Science, Technology, and Research (A*STAR))

  • Jinbing Xie

    (Southeast University)

  • Shenghong Ju

    (Southeast University)

Abstract

Immunotherapy with immune checkpoint blockade (ICB) for glioblastoma (GBM) is promising but its clinical efficacy is seriously challenged by the blood-tumor barrier (BTB) and immunosuppressive tumor microenvironment. Here, anti-programmed death-ligand 1 antibodies (aPD-L1) are loaded into a redox-responsive micelle and the ICB efficacy is further amplified by paclitaxel (PTX)-induced immunogenic cell death (ICD) via a co-encapsulation approach for the reinvigoration of local anti-GBM immune responses. Consequently, the micelles cross the BTB and are retained in the reductive tumor microenvironment without altering the bioactivity of aPD-L1. The ICB efficacy is enhanced by the aPD-L1 and PTX combination with suppression of primary and recurrent GBM, accumulation of cytotoxic T lymphocytes, and induction of long-lasting immunological memory in the orthotopic GBM-bearing mice. The co-encapsulation approach facilitating efficient antibody delivery and combining with chemotherapeutic agent-induced ICD demonstrate that the chemo-immunotherapy might reprogram local immunity to empower immunotherapy against GBM.

Suggested Citation

  • Zhiqi Zhang & Xiaoxuan Xu & Jiawei Du & Xin Chen & Yonger Xue & Jianqiong Zhang & Xue Yang & Xiaoyuan Chen & Jinbing Xie & Shenghong Ju, 2024. "Redox-responsive polymer micelles co-encapsulating immune checkpoint inhibitors and chemotherapeutic agents for glioblastoma therapy," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-44963-3
    DOI: 10.1038/s41467-024-44963-3
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-44963-3
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-024-44963-3?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Jing Qi & Feiyang Jin & Yuchan You & Yan Du & Di Liu & Xiaoling Xu & Jun Wang & Luwen Zhu & Minjiang Chen & Gaofeng Shu & Liming Wu & Jiansong Ji & Yongzhong Du, 2021. "Synergistic effect of tumor chemo-immunotherapy induced by leukocyte-hitchhiking thermal-sensitive micelles," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    2. Ichiko Kinjyo & Jim Qin & Sioh-Yang Tan & Cameron J. Wellard & Paulus Mrass & William Ritchie & Atsushi Doi & Lois L. Cavanagh & Michio Tomura & Asako Sakaue-Sawano & Osami Kanagawa & Atsushi Miyawaki, 2015. "Real-time tracking of cell cycle progression during CD8+ effector and memory T-cell differentiation," Nature Communications, Nature, vol. 6(1), pages 1-13, May.
    3. Verena Turco & Kira Pfleiderer & Jessica Hunger & Natalie K. Horvat & Kianush Karimian-Jazi & Katharina Schregel & Manuel Fischer & Gianluca Brugnara & Kristine Jähne & Volker Sturm & Yannik Streibel , 2023. "T cell-independent eradication of experimental glioma by intravenous TLR7/8-agonist-loaded nanoparticles," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Xiaoqiong Zhang & Zhaohan Wei & Tuying Yong & Shiyu Li & Nana Bie & Jianye Li & Xin Li & Haojie Liu & Hang Xu & Yuchen Yan & Bixiang Zhang & Xiaoping Chen & Xiangliang Yang & Lu Gan, 2023. "Cell microparticles loaded with tumor antigen and resiquimod reprogram tumor-associated macrophages and promote stem-like CD8+ T cells to boost anti-PD-1 therapy," Nature Communications, Nature, vol. 14(1), pages 1-22, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-44963-3. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.