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Non-Faradaic optoelectrodes for safe electrical neuromodulation

Author

Listed:
  • Jian Chen

    (State Key Laboratory of Molecular Engineering of Polymers, Fudan University)

  • Yanyan Liu

    (State Key Laboratory of Molecular Engineering of Polymers, Fudan University
    Fudan University)

  • Feixiang Chen

    (State Key Laboratory of Molecular Engineering of Polymers, Fudan University)

  • Mengnan Guo

    (State Key Laboratory of Molecular Engineering of Polymers, Fudan University)

  • Jiajia Zhou

    (University of Technology Sydney)

  • Pengfei Fu

    (Fudan University)

  • Xin Zhang

    (Fudan University)

  • Xueli Wang

    (Sate Key Laboratory of Precision Spectroscopy, East China Normal University)

  • He Wang

    (Institute of Science and Technology for Brain Inspired Intelligence, Fudan University)

  • Wei Hua

    (Fudan University)

  • Jinquan Chen

    (Sate Key Laboratory of Precision Spectroscopy, East China Normal University)

  • Jin Hu

    (Fudan University)

  • Ying Mao

    (Fudan University)

  • Dayong Jin

    (University of Technology Sydney
    Eastern Institute for Advanced Study, Eastern Institute of Technology)

  • Wenbo Bu

    (State Key Laboratory of Molecular Engineering of Polymers, Fudan University
    Fudan University)

Abstract

Nanoscale optoelectrodes hold the potential to stimulate optically individual neurons and intracellular organelles, a challenge that demands both a high-density of photoelectron storage and significant charge injection. Here, we report that zinc porphyrin, commonly used in dye-sensitized solar cells, can be self-assembled into nanorods and then coated by TiO2. The J-aggregated zinc porphyrin array enables long-range exciton diffusion and allows for fast electron transfer into TiO2. The formation of TiO2(e−) attracts positive charges around the neuron membrane, contributing to the induction of action potentials. Far-field cranial irradiation of the motor cortex using a 670 nm laser or an 850 nm femtosecond laser can modulate local neuronal firing and trigger motor responses in the hind limb of mice. The pulsed photoelectrical stimulation of neurons in the subthalamic nucleus alleviates parkinsonian symptoms in mice, improving abnormal stepping and enhancing the activity of dopaminergic neurons. Our results suggest injectable nanoscopic optoelectrodes for optical neuromodulation with high efficiency and negligible side effects.

Suggested Citation

  • Jian Chen & Yanyan Liu & Feixiang Chen & Mengnan Guo & Jiajia Zhou & Pengfei Fu & Xin Zhang & Xueli Wang & He Wang & Wei Hua & Jinquan Chen & Jin Hu & Ying Mao & Dayong Jin & Wenbo Bu, 2024. "Non-Faradaic optoelectrodes for safe electrical neuromodulation," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-023-44635-8
    DOI: 10.1038/s41467-023-44635-8
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    References listed on IDEAS

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    1. Diego Ghezzi & Maria Rosa Antognazza & Marco Dal Maschio & Erica Lanzarini & Fabio Benfenati & Guglielmo Lanzani, 2011. "A hybrid bioorganic interface for neuronal photoactivation," Nature Communications, Nature, vol. 2(1), pages 1-7, September.
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