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ApoL6 associates with lipid droplets and disrupts Perilipin1-HSL interaction to inhibit lipolysis

Author

Listed:
  • Yuhui Wang

    (University of California, Berkeley)

  • Hai P. Nguyen

    (University of California, Berkeley)

  • Pengya Xue

    (University of California, Berkeley)

  • Ying Xie

    (University of California, Berkeley)

  • Danielle Yi

    (University of California, Berkeley)

  • Frances Lin

    (University of California, Berkeley)

  • Jennie Dinh

    (University of California, Berkeley)

  • Jose A. Viscarra

    (University of California, Berkeley)

  • Nnejiuwa U. Ibe

    (University of California, Berkeley)

  • Robin E. Duncan

    (University of California, Berkeley
    University of Waterloo)

  • Hei S. Sul

    (University of California, Berkeley)

Abstract

Adipose tissue stores triacylglycerol (TAG) in lipid droplets (LD) and release fatty acids upon lipolysis during energy shortage. We identify ApoL6 as a LD-associated protein mainly found in adipose tissue, specifically in adipocytes. ApoL6 expression is low during fasting but induced upon feeding. ApoL6 knockdown results in smaller LD with lower TAG content in adipocytes, while ApoL6 overexpression causes larger LD with higher TAG content. We show that the ApoL6 affects adipocytes through inhibition of lipolysis. While ApoL6, Perilipin 1 (Plin1), and HSL can form a complex on LD, C-terminal ApoL6 directly interacts with N-terminal Plin1 to prevent Plin1 binding to HSL, to inhibit lipolysis. Thus, ApoL6 ablation decreases white adipose tissue mass, protecting mice from diet-induced obesity, while ApoL6 overexpression in adipose brings obesity and insulin resistance, making ApoL6 a potential future target against obesity and diabetes.

Suggested Citation

  • Yuhui Wang & Hai P. Nguyen & Pengya Xue & Ying Xie & Danielle Yi & Frances Lin & Jennie Dinh & Jose A. Viscarra & Nnejiuwa U. Ibe & Robin E. Duncan & Hei S. Sul, 2024. "ApoL6 associates with lipid droplets and disrupts Perilipin1-HSL interaction to inhibit lipolysis," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-023-44559-3
    DOI: 10.1038/s41467-023-44559-3
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    References listed on IDEAS

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    1. Martina Schweiger & Matthias Romauch & Renate Schreiber & Gernot F. Grabner & Sabrina Hütter & Petra Kotzbeck & Pia Benedikt & Thomas O. Eichmann & Sohsuke Yamada & Oskar Knittelfelder & Clemens Diwok, 2017. "Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice," Nature Communications, Nature, vol. 8(1), pages 1-15, April.
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