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BCG vaccination-induced acquired control of mycobacterial growth differs from growth control preexisting to BCG vaccination

Author

Listed:
  • Krista E. Meijgaarden

    (Leiden University Medical Center)

  • Wenchao Li

    (Centre for Individualised Infection Medicine (CiiM), a joint venture between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH)
    TWINCORE, a joint venture between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH))

  • Simone J. C. F. M. Moorlag

    (Radboud University Medical Center)

  • Valerie A. C. M. Koeken

    (Centre for Individualised Infection Medicine (CiiM), a joint venture between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH)
    TWINCORE, a joint venture between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH)
    Radboud University Medical Center
    Research Centre Innovations in Care, Rotterdam University of Applied Sciences)

  • Hans J. P. M. Koenen

    (Radboud University Medical Center)

  • Leo A. B. Joosten

    (Radboud University Medical Center
    Iuliu Hatieganu University of Medicine and Pharmacy)

  • Annapurna Vyakarnam

    (Indian Institute of Science
    Division of Infectious Diseases, St. John’s Research Institute
    School of Immunology & Microbial Sciences, Faculty of Life Science & Medicine, King’s College)

  • Asma Ahmed

    (Indian Institute of Science
    Division of Infectious Diseases, St. John’s Research Institute)

  • Srabanti Rakshit

    (Indian Institute of Science
    Division of Infectious Diseases, St. John’s Research Institute)

  • Vasista Adiga

    (Indian Institute of Science
    Division of Infectious Diseases, St. John’s Research Institute)

  • Tom H. M. Ottenhoff

    (Leiden University Medical Center)

  • Yang Li

    (Centre for Individualised Infection Medicine (CiiM), a joint venture between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH)
    TWINCORE, a joint venture between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH)
    Radboud University Medical Center)

  • Mihai G. Netea

    (Radboud University Medical Center
    Life and Medical Sciences Institute, University of Bonn)

  • Simone A. Joosten

    (Leiden University Medical Center)

Abstract

Bacillus Calmette-Guèrin - vaccination induces not only protection in infants and young children against severe forms of tuberculosis, but also against non-tuberculosis related all-cause mortality. To delineate different factors influencing mycobacterial growth control, here we first investigate the effects of BCG-vaccination in healthy Dutch adults. About a quarter of individuals already control BCG-growth prior to vaccination, whereas a quarter of the vaccinees acquires the capacity to control BCG upon vaccination. This leaves half of the population incapable to control BCG-growth. Single cell RNA sequencing identifies multiple processes associated with mycobacterial growth control. These data suggest (i) that already controllers employ different mechanisms to control BCG-growth than acquired controllers, and (ii) that half of the individuals fail to develop measurable growth control irrespective of BCG-vaccination. These results shed important new light on the variable immune responses to mycobacteria in humans and may impact on improved vaccination against tuberculosis and other diseases.

Suggested Citation

  • Krista E. Meijgaarden & Wenchao Li & Simone J. C. F. M. Moorlag & Valerie A. C. M. Koeken & Hans J. P. M. Koenen & Leo A. B. Joosten & Annapurna Vyakarnam & Asma Ahmed & Srabanti Rakshit & Vasista Adi, 2024. "BCG vaccination-induced acquired control of mycobacterial growth differs from growth control preexisting to BCG vaccination," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-023-44252-5
    DOI: 10.1038/s41467-023-44252-5
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    References listed on IDEAS

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    1. Jona Walk & L. Charlotte J. Bree & Wouter Graumans & Rianne Stoter & Geert-Jan Gemert & Marga Vegte-Bolmer & Karina Teelen & Cornelus C. Hermsen & Rob J. W. Arts & Marije C. Behet & Farid Keramati & S, 2019. "Outcomes of controlled human malaria infection after BCG vaccination," Nature Communications, Nature, vol. 10(1), pages 1-8, December.
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