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A unique sigma/anti-sigma system in the actinomycete Actinoplanes missouriensis

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  • Takeaki Tezuka

    (The University of Tokyo
    Kitasato University)

  • Kyota Mitsuyama

    (The University of Tokyo)

  • Risa Date

    (The University of Tokyo)

  • Yasuo Ohnishi

    (The University of Tokyo
    The University of Tokyo)

Abstract

Bacteria of the genus Actinoplanes form sporangia that contain dormant sporangiospores which, upon contact with water, release motile spores (zoospores) through a process called sporangium dehiscence. Here, we set out to study the molecular mechanisms behind sporangium dehiscence in Actinoplanes missouriensis and discover a sigma/anti-sigma system with unique features. Protein σSsdA contains a functional sigma factor domain and an anti-sigma factor antagonist domain, while protein SipA contains an anti-sigma factor domain and an anti-sigma factor antagonist domain. Remarkably, the two proteins interact with each other via the anti-sigma factor antagonist domain of σSsdA and the anti-sigma factor domain of SipA. Although it remains unclear whether the SipA/σSsdA system plays direct roles in sporangium dehiscence, the system seems to modulate oxidative stress responses in zoospores. In addition, we identify a two-component regulatory system (RsdK-RsdR) that represses initiation of sporangium dehiscence.

Suggested Citation

  • Takeaki Tezuka & Kyota Mitsuyama & Risa Date & Yasuo Ohnishi, 2023. "A unique sigma/anti-sigma system in the actinomycete Actinoplanes missouriensis," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-44291-y
    DOI: 10.1038/s41467-023-44291-y
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    References listed on IDEAS

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    1. Lior Artzi & Assaf Alon & Kelly P. Brock & Anna G. Green & Amy Tam & Fernando H. Ramírez-Guadiana & Debora Marks & Andrew Kruse & David Z. Rudner, 2021. "Dormant spores sense amino acids through the B subunits of their germination receptors," Nature Communications, Nature, vol. 12(1), pages 1-8, December.
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