IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-43758-2.html
   My bibliography  Save this article

Young infants display heterogeneous serological responses and extensive but reversible transcriptional changes following initial immunizations

Author

Listed:
  • Nima Nouri

    (The Jackson Laboratory for Genomic Medicine
    Precision Medicine and Computational Biology, Sanofi)

  • Raquel Giacomelli Cao

    (Abigail Wexner Research Institute at Nationwide Children’s Hospital
    Nationwide Children’s Hospital, and The Ohio State University College of Medicine)

  • Eleonora Bunsow

    (Abigail Wexner Research Institute at Nationwide Children’s Hospital)

  • Djamel Nehar-Belaid

    (The Jackson Laboratory for Genomic Medicine)

  • Radu Marches

    (The Jackson Laboratory for Genomic Medicine)

  • Zhaohui Xu

    (Abigail Wexner Research Institute at Nationwide Children’s Hospital
    St. Jude Children’s Research Hospital)

  • Bennett Smith

    (Abigail Wexner Research Institute at Nationwide Children’s Hospital)

  • Santtu Heinonen

    (Abigail Wexner Research Institute at Nationwide Children’s Hospital
    Helsinki University Hospital and University of Helsinki)

  • Sara Mertz

    (Abigail Wexner Research Institute at Nationwide Children’s Hospital)

  • Amy Leber

    (Nationwide Children’s Hospital)

  • Gaby Smits

    (National Institute for Public Health and the Environment (RIVM))

  • Fiona Klis

    (National Institute for Public Health and the Environment (RIVM))

  • Asunción Mejías

    (Abigail Wexner Research Institute at Nationwide Children’s Hospital
    Nationwide Children’s Hospital, and The Ohio State University College of Medicine
    St. Jude Children’s Research Hospital)

  • Jacques Banchereau

    (The Jackson Laboratory for Genomic Medicine
    Immunai)

  • Virginia Pascual

    (Weill Cornell Medicine)

  • Octavio Ramilo

    (Abigail Wexner Research Institute at Nationwide Children’s Hospital
    Nationwide Children’s Hospital, and The Ohio State University College of Medicine
    St. Jude Children’s Research Hospital)

Abstract

Infants necessitate vaccinations to prevent life-threatening infections. Our understanding of the infant immune responses to routine vaccines remains limited. We analyzed two cohorts of 2-month-old infants before vaccination, one week, and one-month post-vaccination. We report remarkable heterogeneity but limited antibody responses to the different antigens. Whole-blood transcriptome analysis in an initial cohort showed marked overexpression of interferon-stimulated genes (ISGs) and to a lesser extent of inflammation-genes at day 7, which normalized one month post-vaccination. Single-cell RNA sequencing in peripheral blood mononuclear cells from a second cohort identified at baseline a predominantly naive immune landscape including ISGhi cells. On day 7, increased expression of interferon-, inflammation-, and cytotoxicity-related genes were observed in most immune cells, that reverted one month post-vaccination, when a CD8+ ISGhi and cytotoxic cluster and B cells expanded. Antibody responses were associated with baseline frequencies of plasma cells, B-cells, and monocytes, and induction of ISGs at day 7.

Suggested Citation

  • Nima Nouri & Raquel Giacomelli Cao & Eleonora Bunsow & Djamel Nehar-Belaid & Radu Marches & Zhaohui Xu & Bennett Smith & Santtu Heinonen & Sara Mertz & Amy Leber & Gaby Smits & Fiona Klis & Asunción M, 2023. "Young infants display heterogeneous serological responses and extensive but reversible transcriptional changes following initial immunizations," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43758-2
    DOI: 10.1038/s41467-023-43758-2
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-43758-2
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-023-43758-2?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43758-2. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.