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Eicosanoid and eicosanoid-related inflammatory mediators and exercise intolerance in heart failure with preserved ejection fraction

Author

Listed:
  • Emily S. Lau

    (Massachusetts General Hospital
    Massachusetts General Hospital)

  • Athar Roshandelpoor

    (Beth Israel Deaconess Medical Center)

  • Shahrooz Zarbafian

    (Massachusetts General Hospital
    Google LLC, 1600 Amphitheatre Parkway)

  • Dongyu Wang

    (Beth Israel Deaconess Medical Center
    Boston University School of Public Health)

  • James S. Guseh

    (Massachusetts General Hospital
    Massachusetts General Hospital)

  • Norrina Allen

    (Northwestern University Feinberg School of Medicine)

  • Vinithra Varadarajan

    (Department of Medicine Johns Hopkins University School of Medicine)

  • Matthew Nayor

    (Boston University School of Medicine)

  • Ravi V. Shah

    (Vanderbilt University Medical Center)

  • Joao A. C. Lima

    (Department of Medicine Johns Hopkins University School of Medicine)

  • Sanjiv J. Shah

    (Northwestern University Feinberg School of Medicine
    Northwestern University Feinberg School of Medicine)

  • Bing Yu

    (University of Texas Health School of Public Health)

  • Mona Alotaibi

    (University of California San Diego)

  • Susan Cheng

    (Cedars-Sinai Medical Center)

  • Mohit Jain

    (University of California San Diego)

  • Gregory D. Lewis

    (Massachusetts General Hospital
    Massachusetts General Hospital)

  • Jennifer E. Ho

    (Massachusetts General Hospital)

Abstract

Systemic inflammation has been implicated in the pathobiology of heart failure with preserved ejection fraction (HFpEF). Here, we examine the association of upstream mediators of inflammation as ascertained by fatty-acid derived eicosanoid and eicosanoid-related metabolites with HFpEF status and exercise manifestations of HFpEF. Among 510 participants with chronic dyspnea and preserved LVEF who underwent invasive cardiopulmonary exercise testing, we find that 70 of 890 eicosanoid and related metabolites are associated with HFpEF status, including 17 named and 53 putative eicosanoids (FDR q-value

Suggested Citation

  • Emily S. Lau & Athar Roshandelpoor & Shahrooz Zarbafian & Dongyu Wang & James S. Guseh & Norrina Allen & Vinithra Varadarajan & Matthew Nayor & Ravi V. Shah & Joao A. C. Lima & Sanjiv J. Shah & Bing Y, 2023. "Eicosanoid and eicosanoid-related inflammatory mediators and exercise intolerance in heart failure with preserved ejection fraction," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43363-3
    DOI: 10.1038/s41467-023-43363-3
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