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Fatty acid desaturation and lipoxygenase pathways support trained immunity

Author

Listed:
  • Anaísa V. Ferreira

    (Radboud University Nijmegen Medical Center
    Universidade do Porto)

  • Juan Carlos Alarcon-Barrera

    (Leiden University Medical Center)

  • Jorge Domínguez-Andrés

    (Radboud University Nijmegen Medical Center)

  • Özlem Bulut

    (Radboud University Nijmegen Medical Center)

  • Gizem Kilic

    (Radboud University Nijmegen Medical Center)

  • Priya A. Debisarun

    (Radboud University Nijmegen Medical Center)

  • Rutger J. Röring

    (Radboud University Nijmegen Medical Center)

  • Hatice N. Özhan

    (Radboud University Nijmegen Medical Center)

  • Eva Terschlüsen

    (Radboud University Medical Centre)

  • Athanasios Ziogas

    (Radboud University Nijmegen Medical Center)

  • Sarantos Kostidis

    (Leiden University Medical Center)

  • Yassene Mohammed

    (Leiden University Medical Center)

  • Vasiliki Matzaraki

    (Radboud University Nijmegen Medical Center)

  • George Renieris

    (National and Kapodistrian University of Athens, Medical School)

  • Evangelos J. Giamarellos-Bourboulis

    (National and Kapodistrian University of Athens, Medical School)

  • Mihai G. Netea

    (Radboud University Nijmegen Medical Center
    University of Bonn)

  • Martin Giera

    (Leiden University Medical Center)

Abstract

Infections and vaccines can induce enhanced long-term responses in innate immune cells, establishing an innate immunological memory termed trained immunity. Here, we show that monocytes with a trained immunity phenotype, due to exposure to the Bacillus Calmette-Guérin (BCG) vaccine, are characterized by an increased biosynthesis of different lipid mediators (LM) derived from long-chain polyunsaturated fatty acids (PUFA). Pharmacological and genetic approaches show that long-chain PUFA synthesis and lipoxygenase-derived LM are essential for the BCG-induced trained immunity responses of human monocytes. Furthermore, products of 12-lipoxygenase activity increase in monocytes of healthy individuals after BCG vaccination. Grasping the underscoring lipid metabolic pathways contributes to our understanding of trained immunity and may help to identify therapeutic tools and targets for the modulation of innate immune responses.

Suggested Citation

  • Anaísa V. Ferreira & Juan Carlos Alarcon-Barrera & Jorge Domínguez-Andrés & Özlem Bulut & Gizem Kilic & Priya A. Debisarun & Rutger J. Röring & Hatice N. Özhan & Eva Terschlüsen & Athanasios Ziogas & , 2023. "Fatty acid desaturation and lipoxygenase pathways support trained immunity," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43315-x
    DOI: 10.1038/s41467-023-43315-x
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    References listed on IDEAS

    as
    1. Paras S. Minhas & Amira Latif-Hernandez & Melanie R. McReynolds & Aarooran S. Durairaj & Qian Wang & Amanda Rubin & Amit U. Joshi & Joy Q. He & Esha Gauba & Ling Liu & Congcong Wang & Miles Linde & Yu, 2021. "Restoring metabolism of myeloid cells reverses cognitive decline in ageing," Nature, Nature, vol. 590(7844), pages 122-128, February.
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