Author
Listed:
- Ting-Ting Gong
(Shengjing Hospital of China Medical University)
- Shuang Guo
(Harbin Medical University)
- Fang-Hua Liu
(Shengjing Hospital of China Medical University
Shengjing Hospital of China Medical University
Shengjing Hospital of China Medical University)
- Yun-Long Huo
(Shengjing Hospital of China Medical University)
- Meng Zhang
(Shengjing Hospital of China Medical University
Shengjing Hospital of China Medical University
Shengjing Hospital of China Medical University)
- Shi Yan
(Shengjing Hospital of China Medical University
Shengjing Hospital of China Medical University
Shengjing Hospital of China Medical University)
- Han-Xiao Zhou
(Harbin Medical University)
- Xu Pan
(Harbin Medical University)
- Xin-Yue Wang
(Harbin Medical University)
- He-Li Xu
(Shengjing Hospital of China Medical University
Shengjing Hospital of China Medical University
Shengjing Hospital of China Medical University)
- Ye Kang
(Shengjing Hospital of China Medical University)
- Yi-Zi Li
(Shengjing Hospital of China Medical University
Shengjing Hospital of China Medical University
Shengjing Hospital of China Medical University)
- Xue Qin
(Shengjing Hospital of China Medical University)
- Qian Xiao
(Shengjing Hospital of China Medical University
Shengjing Hospital of China Medical University)
- Dong-Hui Huang
(Shengjing Hospital of China Medical University
Shengjing Hospital of China Medical University
Shengjing Hospital of China Medical University)
- Xiao-Ying Li
(Shengjing Hospital of China Medical University
Shengjing Hospital of China Medical University
Shengjing Hospital of China Medical University)
- Yue-Yang Zhao
(Shengjing Hospital of China Medical University)
- Xin-Xin Zhao
(Shengjing Hospital of China Medical University)
- Ya-Li Wang
(Shengjing Hospital of China Medical University)
- Xiao-Xin Ma
(Shengjing Hospital of China Medical University)
- Song Gao
(Shengjing Hospital of China Medical University)
- Yu-Hong Zhao
(Shengjing Hospital of China Medical University
Shengjing Hospital of China Medical University
Shengjing Hospital of China Medical University)
- Shang-Wei Ning
(Harbin Medical University)
- Qi-Jun Wu
(Shengjing Hospital of China Medical University
Shengjing Hospital of China Medical University
Shengjing Hospital of China Medical University
Shengjing Hospital of China Medical University)
Abstract
Clear cell carcinoma (CCC), endometrioid carcinoma (EC), and serous carcinoma (SC) are the major histological subtypes of epithelial ovarian cancer (EOC), whose differences in carcinogenesis are still unclear. Here, we undertake comprehensive proteomic profiling of 80 CCC, 79 EC, 80 SC, and 30 control samples. Our analysis reveals the prognostic or diagnostic value of dysregulated proteins and phosphorylation sites in important pathways. Moreover, protein co-expression network not only provides comprehensive view of biological features of each histological subtype, but also indicates potential prognostic biomarkers and progression landmarks. Notably, EOC have strong inter-tumor heterogeneity, with significantly different clinical characteristics, proteomic patterns and signaling pathway disorders in CCC, EC, and SC. Finally, we infer MPP7 protein as potential therapeutic target for SC, whose biological functions are confirmed in SC cells. Our proteomic cohort provides valuable resources for understanding molecular mechanisms and developing treatment strategies of distinct histological subtypes.
Suggested Citation
Ting-Ting Gong & Shuang Guo & Fang-Hua Liu & Yun-Long Huo & Meng Zhang & Shi Yan & Han-Xiao Zhou & Xu Pan & Xin-Yue Wang & He-Li Xu & Ye Kang & Yi-Zi Li & Xue Qin & Qian Xiao & Dong-Hui Huang & Xiao-Y, 2023.
"Proteomic characterization of epithelial ovarian cancer delineates molecular signatures and therapeutic targets in distinct histological subtypes,"
Nature Communications, Nature, vol. 14(1), pages 1-15, December.
Handle:
RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43282-3
DOI: 10.1038/s41467-023-43282-3
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