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Enhancement and contextual modulation of visuospatial processing by thalamocollicular projections from ventral lateral geniculate nucleus

Author

Listed:
  • Zhong Li

    (University of Southern California)

  • Bo Peng

    (University of Southern California
    University of Southern California)

  • Junxiang J. Huang

    (University of Southern California
    University of Southern California)

  • Yuan Zhang

    (University of Southern California)

  • Michelle B. Seo

    (University of Southern California
    University of Southern California)

  • Qi Fang

    (University of Southern California
    University of Southern California)

  • Guang-Wei Zhang

    (University of Southern California)

  • Xiaohui Zhang

    (Beijing Normal University)

  • Li I. Zhang

    (University of Southern California
    University of Southern California)

  • Huizhong Whit Tao

    (University of Southern California
    University of Southern California)

Abstract

In the mammalian visual system, the ventral lateral geniculate nucleus (vLGN) of the thalamus receives salient visual input from the retina and sends prominent GABAergic axons to the superior colliculus (SC). However, whether and how vLGN contributes to fundamental visual information processing remains largely unclear. Here, we report in mice that vLGN facilitates visually-guided approaching behavior mediated by the lateral SC and enhances the sensitivity of visual object detection. This can be attributed to the extremely broad spatial integration of vLGN neurons, as reflected in their much lower preferred spatial frequencies and broader spatial receptive fields than SC neurons. Through GABAergic thalamocollicular projections, vLGN specifically exerts prominent surround suppression of visuospatial processing in SC, leading to a fine tuning of SC preferences to higher spatial frequencies and smaller objects in a context-dependent manner. Thus, as an essential component of the central visual processing pathway, vLGN serves to refine and contextually modulate visuospatial processing in SC-mediated visuomotor behaviors via visually-driven long-range feedforward inhibition.

Suggested Citation

  • Zhong Li & Bo Peng & Junxiang J. Huang & Yuan Zhang & Michelle B. Seo & Qi Fang & Guang-Wei Zhang & Xiaohui Zhang & Li I. Zhang & Huizhong Whit Tao, 2023. "Enhancement and contextual modulation of visuospatial processing by thalamocollicular projections from ventral lateral geniculate nucleus," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43147-9
    DOI: 10.1038/s41467-023-43147-9
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    References listed on IDEAS

    as
    1. Zhong Li & Jin-Xing Wei & Guang-Wei Zhang & Junxiang J. Huang & Brian Zingg & Xiyue Wang & Huizhong W. Tao & Li I. Zhang, 2021. "Corticostriatal control of defense behavior in mice induced by auditory looming cues," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    2. Li Shen & Guang-Wei Zhang & Can Tao & Michelle B. Seo & Nicole K. Zhang & Junxiang J. Huang & Li I. Zhang & Huizhong W. Tao, 2022. "A bottom-up reward pathway mediated by somatostatin neurons in the medial septum complex underlying appetitive learning," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
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    Cited by:

    1. Can Tao & Guang-Wei Zhang & Wen-Jian Sun & Junxiang J. Huang & Li I. Zhang & Huizhong Whit Tao, 2024. "Excitation-inhibition imbalance in medial preoptic area circuits underlies chronic stress-induced depression-like states," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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