IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-43072-x.html
   My bibliography  Save this article

The alarmin IL33 orchestrates type 2 immune-mediated control of thymus regeneration

Author

Listed:
  • Emilie J. Cosway

    (University of Birmingham)

  • Kieran D. James

    (University of Birmingham)

  • Andrea J. White

    (University of Birmingham)

  • Sonia M. Parnell

    (University of Birmingham)

  • Andrea Bacon

    (University of Birmingham)

  • Andrew N. J. McKenzie

    (MRC Laboratory of Molecular Biology)

  • W. E. Jenkinson

    (University of Birmingham)

  • Graham Anderson

    (University of Birmingham)

Abstract

As the primary site of T-cell development, the thymus dictates immune competency of the host. The rates of thymus function are not constant, and thymus regeneration is essential to restore new T-cell production following tissue damage from environmental factors and therapeutic interventions. Here, we show the alarmin interleukin (IL) 33 is a product of Sca1+ thymic mesenchyme both necessary and sufficient for thymus regeneration via a type 2 innate immune network. IL33 stimulates expansion of IL5-producing type 2 innate lymphoid cells (ILC2), which triggers a cellular switch in the intrathymic availability of IL4. This enables eosinophil production of IL4 to re-establish thymic mesenchyme prior to recovery of thymopoiesis-inducing epithelial compartments. Collectively, we identify a positive feedback mechanism of type 2 innate immunity that regulates the recovery of thymus function following tissue injury.

Suggested Citation

  • Emilie J. Cosway & Kieran D. James & Andrea J. White & Sonia M. Parnell & Andrea Bacon & Andrew N. J. McKenzie & W. E. Jenkinson & Graham Anderson, 2023. "The alarmin IL33 orchestrates type 2 immune-mediated control of thymus regeneration," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43072-x
    DOI: 10.1038/s41467-023-43072-x
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-43072-x
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-023-43072-x?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Thomas Venables & Ann V. Griffith & Alice DeAraujo & Howard T. Petrie, 2019. "Dynamic changes in epithelial cell morphology control thymic organ size during atrophy and regeneration," Nature Communications, Nature, vol. 10(1), pages 1-15, December.
    2. Wong Yu & Hitoshi Nagaoka & Mila Jankovic & Ziva Misulovin & Heikyung Suh & Antonius Rolink & Fritz Melchers & Eric Meffre & Michel C. Nussenzweig, 1999. "Continued RAG expression in late stages of B cell development and no apparent re-induction after immunizion," Nature, Nature, vol. 400(6745), pages 682-687, August.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Chen Chen & Bongsoo Park & Emeline Ragonnaud & Monica Bodogai & Xin Wang & Le Zong & Jung-Min Lee & Isabel Beerman & Arya Biragyn, 2022. "Cancer co-opts differentiation of B-cell precursors into macrophage-like cells," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Alexia Borelli & Jérémy C. Santamaria & Cloé Zamit & Cécile Apert & Jessica Chevallier & Philippe Pierre & Rafael J. Argüello & Lionel Spinelli & Magali Irla, 2024. "Lymphotoxin limits Foxp3+ regulatory T cell development from Foxp3lo precursors via IL-4 signaling," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43072-x. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.