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Pathogenesis-adaptive polydopamine nanosystem for sequential therapy of ischemic stroke

Author

Listed:
  • Di Wu

    (Zhejiang Chinese Medical University)

  • Jing Zhou

    (Zhejiang Chinese Medical University)

  • Yanrong Zheng

    (Zhejiang Chinese Medical University)

  • Yuyi Zheng

    (Zhejiang Chinese Medical University)

  • Qi Zhang

    (Zhejiang Chinese Medical University)

  • Zhuchen Zhou

    (Zhejiang Chinese Medical University)

  • Xiaojie Chen

    (Zhejiang Chinese Medical University)

  • Qi Chen

    (Zhejiang Chinese Medical University)

  • Yeping Ruan

    (Zhejiang Chinese Medical University)

  • Yi Wang

    (Zhejiang Chinese Medical University
    The Third Affiliated Hospital of Zhejiang Chinese Medical University)

  • Zhong Chen

    (Zhejiang Chinese Medical University)

Abstract

Ischemic stroke is lethal cerebrovascular disease, and reperfusion as the main strategy of blood supply restoration can cause severe ischemic brain damage. Considered as the major obstacle in medication for stroke, neuroinflammation after reperfusion undergoes dynamic progression, making precision treatment for stroke a Herculean task. In this work, we report a pathogenesis-adaptive polydopamine nanosystem for sequential therapy of ischemic stroke. Intrinsic free radical scavenging and tailored mesostructure of the nanosystem can attenuate oxidative stress at the initial stage. Upon microglial overactivation at the later stage, minocycline-loaded nanosystem can timely reverse the pro-inflammatory transition in response to activated matrix metalloproteinase-2, providing on-demand regulation. Further in vivo stroke study demonstrates a higher survival rate and improved brain recovery of the sequential strategy, compared with mono-therapy and combined therapy. Complemented with satisfactory biosafety results, this adaptive nanosystem for sequential and on-demand regulation of post-stroke neuroinflammation is a promising approach to ischemic stroke therapy.

Suggested Citation

  • Di Wu & Jing Zhou & Yanrong Zheng & Yuyi Zheng & Qi Zhang & Zhuchen Zhou & Xiaojie Chen & Qi Chen & Yeping Ruan & Yi Wang & Zhong Chen, 2023. "Pathogenesis-adaptive polydopamine nanosystem for sequential therapy of ischemic stroke," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43070-z
    DOI: 10.1038/s41467-023-43070-z
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    References listed on IDEAS

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    1. Haijing Yan & Xiangnan Zhang & Weiwei Hu & Jing Ma & Weiwei Hou & Xingzhou Zhang & Xiaofen Wang & Jieqiong Gao & Yao Shen & Jianxin Lv & Hiroshi Ohtsu & Feng Han & Guanghui Wang & Zhong Chen, 2014. "Histamine H3 receptors aggravate cerebral ischaemic injury by histamine-independent mechanisms," Nature Communications, Nature, vol. 5(1), pages 1-12, May.
    2. Andrea S. Carlini & Roberto Gaetani & Rebecca L. Braden & Colin Luo & Karen L. Christman & Nathan C. Gianneschi, 2019. "Enzyme-responsive progelator cyclic peptides for minimally invasive delivery to the heart post-myocardial infarction," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
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    1. Xiaolong Gao & Huan Wei & Wenjie Ma & Wenjie Wu & Wenliang Ji & Junjie Mao & Ping Yu & Lanqun Mao, 2024. "Inflammation-free electrochemical in vivo sensing of dopamine with atomic-level engineered antioxidative single-atom catalyst," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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