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Binge-pattern alcohol consumption and genetic risk as determinants of alcohol-related liver disease

Author

Listed:
  • Chengyi Ding

    (University College London)

  • Linda Ng Fat

    (University College London)

  • Annie Britton

    (University College London)

  • Pek Kei Im

    (University of Oxford)

  • Kuang Lin

    (University of Oxford)

  • Anya Topiwala

    (University of Oxford)

  • Liming Li

    (Peking University Health Science Center
    Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education
    Peking University Center for Public Health and Epidemic Preparedness & Response)

  • Zhengming Chen

    (University of Oxford
    University of Oxford)

  • Iona Y. Millwood

    (University of Oxford
    University of Oxford)

  • Steven Bell

    (University of Cambridge
    University of Cambridge)

  • Gautam Mehta

    (University College London
    Foundation for Liver Research
    Royal Free London NHS Foundation Trust)

Abstract

Alcohol-related liver disease (ARLD) represents a major public health burden. Identification of high-risk individuals would allow efficient targeting of public health interventions. Here, we show significant interactions between pattern of drinking, genetic predisposition (polygenic risk score, PRS) and diabetes mellitus, and risk of incident ARLD, in 312,599 actively drinking adults in UK Biobank. Binge and heavy binge drinking significantly increase the risk of alcohol-related cirrhosis (ARC), with higher genetic predisposition further amplifying the risk. Further, we demonstrate a pronounced interaction between heavy binge drinking and high PRS, resulting in a relative excess risk due to interaction (RERI) of 6.07. Diabetes consistently elevates ARC risk across all drinking and PRS categories, and showed significant interaction with both binge patterns and genetic risk. Overall, we demonstrate synergistic effects of binge drinking, genetics, and diabetes on ARC, with potential to identify high-risk individuals for targeted interventions.

Suggested Citation

  • Chengyi Ding & Linda Ng Fat & Annie Britton & Pek Kei Im & Kuang Lin & Anya Topiwala & Liming Li & Zhengming Chen & Iona Y. Millwood & Steven Bell & Gautam Mehta, 2023. "Binge-pattern alcohol consumption and genetic risk as determinants of alcohol-related liver disease," Nature Communications, Nature, vol. 14(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43064-x
    DOI: 10.1038/s41467-023-43064-x
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