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Petal size is controlled by the MYB73/TPL/HDA19-miR159-CKX6 module regulating cytokinin catabolism in Rosa hybrida

Author

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  • Weikun Jing

    (China Agricultural University
    Flower Research Institute of Yunnan Academy of Agricultural Sciences
    Shenzhen Polytechnic)

  • Feifei Gong

    (China Agricultural University)

  • Guoqin Liu

    (China Agricultural University
    Henan Agricultural University)

  • Yinglong Deng

    (China Agricultural University)

  • Jiaqi Liu

    (China Agricultural University)

  • Wenjing Yang

    (China Agricultural University)

  • Xiaoming Sun

    (China Agricultural University)

  • Yonghong Li

    (Shenzhen Polytechnic)

  • Junping Gao

    (China Agricultural University)

  • Xiaofeng Zhou

    (China Agricultural University)

  • Nan Ma

    (China Agricultural University)

Abstract

The size of plant lateral organs is determined by well-coordinated cell proliferation and cell expansion. Here, we report that miR159, an evolutionarily conserved microRNA, plays an essential role in regulating cell division in rose (Rosa hybrida) petals by modulating cytokinin catabolism. We uncover that Cytokinin Oxidase/Dehydrogenase6 (CKX6) is a target of miR159 in petals. Knocking down miR159 levels results in the accumulation of CKX6 transcripts and earlier cytokinin clearance, leading to a shortened cell division period and smaller petals. Conversely, knocking down CKX6 causes cytokinin accumulation and a prolonged developmental cell division period, mimicking the effects of exogenous cytokinin application. MYB73, a R2R3-type MYB transcription repressor, recruits a co-repressor (TOPLESS) and a histone deacetylase (HDA19) to form a suppression complex, which regulates MIR159 expression by modulating histone H3 lysine 9 acetylation levels at the MIR159 promoter. Our work sheds light on mechanisms for ensuring the correct timing of the exit from the cell division phase and thus organ size regulation by controlling cytokinin catabolism.

Suggested Citation

  • Weikun Jing & Feifei Gong & Guoqin Liu & Yinglong Deng & Jiaqi Liu & Wenjing Yang & Xiaoming Sun & Yonghong Li & Junping Gao & Xiaofeng Zhou & Nan Ma, 2023. "Petal size is controlled by the MYB73/TPL/HDA19-miR159-CKX6 module regulating cytokinin catabolism in Rosa hybrida," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42914-y
    DOI: 10.1038/s41467-023-42914-y
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    References listed on IDEAS

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    1. Koichiro Aya & Yuji Hiwatashi & Mikiko Kojima & Hitoshi Sakakibara & Miyako Ueguchi-Tanaka & Mitsuyasu Hasebe & Makoto Matsuoka, 2011. "The Gibberellin perception system evolved to regulate a pre-existing GAMYB-mediated system during land plant evolution," Nature Communications, Nature, vol. 2(1), pages 1-9, September.
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