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Development and validation of an age-sex-ethnicity-specific metabolic syndrome score in the Chinese adults

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Listed:
  • Shujuan Yang

    (Sichuan University
    Wuhan University)

  • Bin Yu

    (Wuhan University
    Sichuan University)

  • Wanqi Yu

    (Wuhan University)

  • Shaoqing Dai

    (Wuhan University
    University of Twente)

  • Chuanteng Feng

    (Wuhan University
    Sichuan University)

  • Ying Shao

    (Yunnan Center for Disease Control and Prevention)

  • Xing Zhao

    (Sichuan University)

  • Xiaoqing Li

    (Fujian Provincial Center for Disease Control and Prevention)

  • Tianjing He

    (Hubei Provincial Center for Disease Control and Prevention)

  • Peng Jia

    (Wuhan University
    Wuhan University
    Hubei Luojia Laboratory
    Wuhan University)

Abstract

Metabolic syndrome (MetS) is characterized by metabolic dysfunctions and could predict future risk for cardiovascular diseases (CVDs). However, the traditionally defined dichotomous MetS neither reflected MetS severity nor considered demographic variations. Here we develop a continuous, age-sex-ethnicity-specific MetS score based on continuous measures of the five metabolic dysfunctions (waist circumference [WC], triglycerides [TG], high-density lipoprotein cholesterol [HDL-C], mean arterial pressure [MAP], and fasting blood glucose [FBG]). We find that the weights of metabolic dysfunctions in the score vary across age-sex-ethnicity-specific subgroups, with higher weights for TG, HDL-C, and WC. Each unit increase in the score is associated with increased risks for hyperlipidemia, diabetes, and hypertension, and elevated levels of HbA1c, cholesterol, body mass index, and serum uric acid. The score shows high sensitivity and accuracy for detecting CVD-related risk factors and is validated in different geographical regions. Our study would advance early identification of CVD risks and, more broadly, preventive medicine and sustainable development goals.

Suggested Citation

  • Shujuan Yang & Bin Yu & Wanqi Yu & Shaoqing Dai & Chuanteng Feng & Ying Shao & Xing Zhao & Xiaoqing Li & Tianjing He & Peng Jia, 2023. "Development and validation of an age-sex-ethnicity-specific metabolic syndrome score in the Chinese adults," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42423-y
    DOI: 10.1038/s41467-023-42423-y
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    1. Helena Pham & Thomas Svensson & Ung-il Chung & Akiko Kishi Svensson, 2022. "Sleep Satisfaction May Modify the Association between Metabolic Syndrome and BMI, Respectively, and Occupational Stress in Japanese Office Workers," IJERPH, MDPI, vol. 19(9), pages 1-12, April.
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