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Imaging and multi-omics datasets converge to define different neural progenitor origins for ATRT-SHH subgroups

Author

Listed:
  • María-Jesús Lobón-Iglesias

    (PSL Research University, SIREDO Oncology center, Institut Curie Research Center)

  • Mamy Andrianteranagna

    (PSL Research University, SIREDO Oncology center, Institut Curie Research Center
    PSL Research University, Institut Curie Research Center)

  • Zhi-Yan Han

    (PSL Research University, SIREDO Oncology center, Institut Curie Research Center)

  • Céline Chauvin

    (PSL Research University, SIREDO Oncology center, Institut Curie Research Center)

  • Julien Masliah-Planchon

    (Institut Curie Hospital)

  • Valeria Manriquez

    (PSL Research University, Institut Curie Research Center)

  • Arnault Tauziede-Espariat

    (GHU Paris-Psychiatry and Neurosciences, Sainte-Anne Hospital
    UMR S1266, INSERM, IMA-BRAIN)

  • Sandrina Turczynski

    (PSL Research University, SIREDO Oncology center, Institut Curie Research Center)

  • Rachida Bouarich-Bourimi

    (PSL Research University, SIREDO Oncology center, Institut Curie Research Center)

  • Magali Frah

    (PSL Research University, SIREDO Oncology center, Institut Curie Research Center)

  • Christelle Dufour

    (Gustave Roussy, Paris Saclay University)

  • Thomas Blauwblomme

    (Université de Paris)

  • Liesbeth Cardoen

    (Institut Curie Hospital)

  • Gaelle Pierron

    (Institut Curie Hospital)

  • Laetitia Maillot

    (Institut Curie Hospital)

  • Delphine Guillemot

    (Institut Curie Hospital)

  • Stéphanie Reynaud

    (Institut Curie Hospital)

  • Christine Bourneix

    (Institut Curie Hospital)

  • Célio Pouponnot

    (PSL Research University, Université Paris-Saclay)

  • Didier Surdez

    (PSL Research University, SIREDO Oncology Center, Institut Curie Research Center
    Balgrist University Hospital, Faculty of Medicine, University of Zurich (UZH))

  • Mylene Bohec

    (PSL University)

  • Sylvain Baulande

    (PSL University)

  • Olivier Delattre

    (Institut Curie Hospital
    PSL Research University, SIREDO Oncology Center, Institut Curie Research Center)

  • Eliane Piaggio

    (PSL Research University, Institut Curie Research Center)

  • Olivier Ayrault

    (PSL Research University, Université Paris-Saclay)

  • Joshua J. Waterfall

    (PSL Research University, Institut Curie Research Center
    PSL Research University, Institut Curie Research Center)

  • Nicolas Servant

    (PSL Research University, Institut Curie Research Center)

  • Kevin Beccaria

    (Université de Paris)

  • Volodia Dangouloff-Ros

    (AP-HP, Necker Sick Kids Hospital and Paris Cite Universiy INSERM 1299 and UMR 1163, Institut Imagine)

  • Franck Bourdeaut

    (PSL Research University, SIREDO Oncology center, Institut Curie Research Center
    Institut Curie Hospital, Paris, and Université de Paris)

Abstract

Atypical teratoid rhabdoid tumors (ATRT) are divided into MYC, TYR and SHH subgroups, suggesting diverse lineages of origin. Here, we investigate the imaging of human ATRT at diagnosis and the precise anatomic origin of brain tumors in the Rosa26-CreERT2::Smarcb1flox/flox model. This cross-species analysis points to an extra-cerebral origin for MYC tumors. Additionally, we clearly distinguish SHH ATRT emerging from the cerebellar anterior lobe (CAL) from those emerging from the basal ganglia (BG) and intra-ventricular (IV) regions. Molecular characteristics point to the midbrain-hindbrain boundary as the origin of CAL SHH ATRT, and to the ganglionic eminence as the origin of BG/IV SHH ATRT. Single-cell RNA sequencing on SHH ATRT supports these hypotheses. Trajectory analyses suggest that SMARCB1 loss induces a de-differentiation process mediated by repressors of the neuronal program such as REST, ID and the NOTCH pathway.

Suggested Citation

  • María-Jesús Lobón-Iglesias & Mamy Andrianteranagna & Zhi-Yan Han & Céline Chauvin & Julien Masliah-Planchon & Valeria Manriquez & Arnault Tauziede-Espariat & Sandrina Turczynski & Rachida Bouarich-Bou, 2023. "Imaging and multi-omics datasets converge to define different neural progenitor origins for ATRT-SHH subgroups," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42371-7
    DOI: 10.1038/s41467-023-42371-7
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    References listed on IDEAS

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