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The α-synuclein PET tracer [18F] ACI-12589 distinguishes multiple system atrophy from other neurodegenerative diseases

Author

Listed:
  • Ruben Smith

    (Lund University
    Skåne University Hospital)

  • Francesca Capotosti

    (EPFL Innovation Park)

  • Martin Schain

    (Lund University
    Antaros Medical
    Copenhagen University Hospital)

  • Tomas Ohlsson

    (Skånes University Hospital)

  • Efthymia Vokali

    (EPFL Innovation Park)

  • Jerome Molette

    (EPFL Innovation Park)

  • Tanja Touilloux

    (EPFL Innovation Park)

  • Valerie Hliva

    (EPFL Innovation Park)

  • Ioannis K. Dimitrakopoulos

    (EPFL Innovation Park)

  • Andreas Puschmann

    (Skåne University Hospital
    Lund University
    Lund University)

  • Jonas Jögi

    (Skåne University Hospital)

  • Per Svenningsson

    (Karolinska University Hospital)

  • Mattias Andréasson

    (Karolinska University Hospital)

  • Christine Sandiego

    (Invicro, LLC)

  • David S. Russell

    (Invicro, LLC)

  • Patricia Miranda-Azpiazu

    (Karolinska Institute)

  • Christer Halldin

    (Karolinska Institute)

  • Erik Stomrud

    (Lund University
    Skåne University Hospital)

  • Sara Hall

    (Lund University
    Skåne University Hospital)

  • Klas Bratteby

    (Skånes University Hospital)

  • Elina Tampio L’Estrade

    (Skånes University Hospital)

  • Ruth Luthi-Carter

    (EPFL Innovation Park)

  • Andrea Pfeifer

    (EPFL Innovation Park)

  • Marie Kosco-Vilbois

    (EPFL Innovation Park)

  • Johannes Streffer

    (EPFL Innovation Park
    University of Antwerp)

  • Oskar Hansson

    (Lund University
    Skåne University Hospital)

Abstract

A positron emission tomography (PET) tracer detecting α-synuclein pathology will improve the diagnosis, and ultimately the treatment of α-synuclein-related diseases. Here we show that the PET ligand, [18F]ACI-12589, displays good in vitro affinity and specificity for pathological α-synuclein in tissues from patients with different α-synuclein-related disorders including Parkinson’s disease (PD) and Multiple-System Atrophy (MSA) using autoradiography and radiobinding techniques. In the initial clinical evaluation we include 23 participants with α-synuclein related disorders, 11 with other neurodegenerative disorders and eight controls. In vivo [18F]ACI-12589 demonstrates clear binding in the cerebellar white matter and middle cerebellar peduncles of MSA patients, regions known to be highly affected by α-synuclein pathology, but shows limited binding in PD. The binding statistically separates MSA patients from healthy controls and subjects with other neurodegenerative disorders, including other synucleinopathies. Our results indicate that α-synuclein pathology in MSA can be identified using [18F]ACI-12589 PET imaging, potentially improving the diagnostic work-up of MSA and allowing for detection of drug target engagement in vivo of novel α-synuclein targeting therapies.

Suggested Citation

  • Ruben Smith & Francesca Capotosti & Martin Schain & Tomas Ohlsson & Efthymia Vokali & Jerome Molette & Tanja Touilloux & Valerie Hliva & Ioannis K. Dimitrakopoulos & Andreas Puschmann & Jonas Jögi & P, 2023. "The α-synuclein PET tracer [18F] ACI-12589 distinguishes multiple system atrophy from other neurodegenerative diseases," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42305-3
    DOI: 10.1038/s41467-023-42305-3
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    Cited by:

    1. Sophie E. Mastenbroek & Jacob W. Vogel & Lyduine E. Collij & Geidy E. Serrano & Cécilia Tremblay & Alexandra L. Young & Richard A. Arce & Holly A. Shill & Erika D. Driver-Dunckley & Shyamal H. Mehta &, 2024. "Disease progression modelling reveals heterogeneity in trajectories of Lewy-type α-synuclein pathology," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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