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Molecular imprinting-based indirect fluorescence detection strategy implemented on paper chip for non-fluorescent microcystin

Author

Listed:
  • Bowei Li

    (Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Ji Qi

    (Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Feng Liu

    (Chinese Academy of Sciences)

  • Rongfang Zhao

    (Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Maryam Arabi

    (Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Abbas Ostovan

    (Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Jinming Song

    (Chinese Academy of Sciences
    Chinese Academy of Sciences
    Qingdao National Laboratory for Marine Science and Technology)

  • Xiaoyan Wang

    (Binzhou Medical University)

  • Zhiyang Zhang

    (Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Lingxin Chen

    (Chinese Academy of Sciences
    Chinese Academy of Sciences
    Pilot National Laboratory for Marine Science and Technology)

Abstract

Fluorescence analysis is a fast and sensitive method, and has great potential application in trace detection of environmental toxins. However, many important environmental toxins are non-fluorescent substances, and it is still a challenge to construct a fluorescence detection method for non-fluorescent substances. Here, by means of charge transfer effect and smart molecular imprinting technology, we report a sensitive indirect fluorescent sensing mechanism (IFSM) and microcystin (MC-RR) is selected as a model target. A molecular imprinted thin film is immobilized on the surface of zinc ferrite nanoparticles (ZnFe2O4 NPs) by using arginine, a dummy fragment of MC-RR. By implementation of IFSM on the paper-based microfluidic chip, a versatile platform for the quantitative assay of MC-RR is developed at trace level (the limit of detection of 0.43 μg/L and time of 20 min) in real water samples without any pretreatment. Importantly, the proposed IFSM can be easily modified and extended for the wide variety of species which lack direct interaction with the fluorescent substrate. This work offers the potential possibility to meet the requirements for the on-site analysis and may explore potential applications of molecularly imprinted fluorescent sensors.

Suggested Citation

  • Bowei Li & Ji Qi & Feng Liu & Rongfang Zhao & Maryam Arabi & Abbas Ostovan & Jinming Song & Xiaoyan Wang & Zhiyang Zhang & Lingxin Chen, 2023. "Molecular imprinting-based indirect fluorescence detection strategy implemented on paper chip for non-fluorescent microcystin," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42244-z
    DOI: 10.1038/s41467-023-42244-z
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    References listed on IDEAS

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    1. Jiajia Zhou & Alexey I. Chizhik & Steven Chu & Dayong Jin, 2020. "Single-particle spectroscopy for functional nanomaterials," Nature, Nature, vol. 579(7797), pages 41-50, March.
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