Fibrocystin/Polyductin releases a C-terminal fragment that translocates into mitochondria and suppresses cystogenesis
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DOI: 10.1038/s41467-023-42196-4
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- Laura Onuchic & Valeria Padovano & Giorgia Schena & Vanathy Rajendran & Ke Dong & Xiaojian Shi & Raj Pandya & Victoria Rai & Nikolay P. Gresko & Omair Ahmed & TuKiet T. Lam & Weiwei Wang & Hongying Sh, 2023. "The C-terminal tail of polycystin-1 suppresses cystic disease in a mitochondrial enzyme-dependent fashion," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
- Monika Pema & Luca Drusian & Marco Chiaravalli & Maddalena Castelli & Qin Yao & Sara Ricciardi & Stefan Somlo & Feng Qian & Stefano Biffo & Alessandra Boletta, 2016. "mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex," Nature Communications, Nature, vol. 7(1), pages 1-11, April.
- Sachin Hajarnis & Ronak Lakhia & Matanel Yheskel & Darren Williams & Mehran Sorourian & Xueqing Liu & Karam Aboudehen & Shanrong Zhang & Kara Kersjes & Ryan Galasso & Jian Li & Vivek Kaimal & Steven L, 2017. "microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism," Nature Communications, Nature, vol. 8(1), pages 1-15, April.
- Linhao Ruan & Chuankai Zhou & Erli Jin & Andrei Kucharavy & Ying Zhang & Zhihui Wen & Laurence Florens & Rong Li, 2017. "Cytosolic proteostasis through importing of misfolded proteins into mitochondria," Nature, Nature, vol. 543(7645), pages 443-446, March.
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