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Hypersensitive MR angiography based on interlocking stratagem for diagnosis of cardiac-cerebral vascular diseases

Author

Listed:
  • Peisen Zhang

    (Beijing University of Chemical Technology)

  • Junwei Cheng

    (Beijing University of Chemical Technology)

  • Yijie Lu

    (University of Toronto)

  • Ni Zhang

    (Sichuan University)

  • Xiaoai Wu

    (Sichuan University)

  • Hua Lin

    (Sichuan University)

  • Wei Li

    (Naval Medical University)

  • Jian Wang

    (Peking Union Medical College)

  • Mitchell A. Winnik

    (University of Toronto)

  • Zhihua Gan

    (Beijing University of Chemical Technology)

  • Yi Hou

    (Beijing University of Chemical Technology)

Abstract

Magnetic resonance (MR) angiography is one of the main diagnostic approaches for cardiac-cerebral vascular diseases. Nevertheless, the non-contrast-enhanced MR angiography suffers from its intrinsic problems derived from the blood flow-dependency, while the clinical Gd-chelating contrast agents are limited by their rapid vascular extravasation. Herein, we report a hypersensitive MR angiography strategy based on interlocking stratagem of zwitterionic Gd-chelate contrast agents (PAA-Gd). The longitudinal molar relaxivity of PAA-Gd was 4.6-times higher than that of individual Gd-chelates as well as appropriate blood half-life (73.8 min) and low immunogenicity, enabling sophisticated micro-vessels angiography with a resolution at the order of hundred micrometers. A series of animal models of cardiac-cerebrovascular diseases have been built for imaging studies on a 7.0 T MRI scanner, while the clinical translation potential of PAA-Gd has been evaluated on swine on a 3.0 T clinical MRI scanner. The current studies offer a promising strategy for precise diagnosis of vascular diseases.

Suggested Citation

  • Peisen Zhang & Junwei Cheng & Yijie Lu & Ni Zhang & Xiaoai Wu & Hua Lin & Wei Li & Jian Wang & Mitchell A. Winnik & Zhihua Gan & Yi Hou, 2023. "Hypersensitive MR angiography based on interlocking stratagem for diagnosis of cardiac-cerebral vascular diseases," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41783-9
    DOI: 10.1038/s41467-023-41783-9
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