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Thalamocortical control of cell-type specificity drives circuits for processing whisker-related information in mouse barrel cortex

Author

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  • Timothy R. Young

    (RIKEN Center for Brain Science)

  • Mariko Yamamoto

    (National Institutes of Natural Sciences)

  • Satomi S. Kikuchi

    (RIKEN Center for Brain Science)

  • Aya C. Yoshida

    (RIKEN Center for Brain Science)

  • Takaya Abe

    (RIKEN Center for Biosystems Dynamics Research)

  • Kenichi Inoue

    (RIKEN Center for Biosystems Dynamics Research)

  • Joshua P. Johansen

    (RIKEN Center for Brain Science)

  • Andrea Benucci

    (RIKEN Center for Brain Science
    Queen Mary University of London)

  • Yumiko Yoshimura

    (National Institutes of Natural Sciences)

  • Tomomi Shimogori

    (RIKEN Center for Brain Science)

Abstract

Excitatory spiny stellate neurons are prominently featured in the cortical circuits of sensory modalities that provide high salience and high acuity representations of the environment. These specialized neurons are considered developmentally linked to bottom-up inputs from the thalamus, however, the molecular mechanisms underlying their diversification and function are unknown. Here, we investigated this in mouse somatosensory cortex, where spiny stellate neurons and pyramidal neurons have distinct roles in processing whisker-evoked signals. Utilizing spatial transcriptomics, we identified reciprocal patterns of gene expression which correlated with these cell-types and were linked to innervation by specific thalamic inputs during development. Genetic manipulation that prevents the acquisition of spiny stellate fate highlighted an important role for these neurons in processing distinct whisker signals within functional cortical columns, and as a key driver in the formation of specific whisker-related circuits in the cortex.

Suggested Citation

  • Timothy R. Young & Mariko Yamamoto & Satomi S. Kikuchi & Aya C. Yoshida & Takaya Abe & Kenichi Inoue & Joshua P. Johansen & Andrea Benucci & Yumiko Yoshimura & Tomomi Shimogori, 2023. "Thalamocortical control of cell-type specificity drives circuits for processing whisker-related information in mouse barrel cortex," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41749-x
    DOI: 10.1038/s41467-023-41749-x
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    References listed on IDEAS

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    1. Gabrielle Pouchelon & Frédéric Gambino & Camilla Bellone & Ludovic Telley & Ilaria Vitali & Christian Lüscher & Anthony Holtmaat & Denis Jabaudon, 2014. "Modality-specific thalamocortical inputs instruct the identity of postsynaptic L4 neurons," Nature, Nature, vol. 511(7510), pages 471-474, July.
    2. Takuji Iwasato & Akash Datwani & Alexander M. Wolf & Hiroshi Nishiyama & Yusuke Taguchi & Susumu Tonegawa & Thomas Knöpfel & Reha S. Erzurumlu & Shigeyoshi Itohara, 2000. "Cortex-restricted disruption of NMDAR1 impairs neuronal patterns in the barrel cortex," Nature, Nature, vol. 406(6797), pages 726-731, August.
    3. Shingo Nakazawa & Hidenobu Mizuno & Takuji Iwasato, 2018. "Differential dynamics of cortical neuron dendritic trees revealed by long-term in vivo imaging in neonates," Nature Communications, Nature, vol. 9(1), pages 1-15, December.
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