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The leaderless communication peptide (LCP) class of quorum-sensing peptides is broadly distributed among Firmicutes

Author

Listed:
  • Shifu Aggarwal

    (Houston Methodist Research Institute
    Houston Methodist Hospital)

  • Elaine Huang

    (Houston Methodist Research Institute
    Houston Methodist Hospital)

  • Hackwon Do

    (Houston Methodist Research Institute
    Houston Methodist Hospital
    Korea Polar Research Institute)

  • Nishanth Makthal

    (Houston Methodist Research Institute
    Houston Methodist Hospital)

  • Yanyan Li

    (Muséum National d’Histoire Naturelle)

  • Eric Bapteste

    (Sorbonne Université, CNRS, Muséum National d’Histoire Naturelle)

  • Philippe Lopez

    (Sorbonne Université, CNRS, Muséum National d’Histoire Naturelle)

  • Charles Bernard

    (University of Lausanne)

  • Muthiah Kumaraswami

    (Houston Methodist Research Institute
    Houston Methodist Hospital)

Abstract

The human pathogen Streptococcus pyogenes secretes a short peptide (leaderless communication peptide, LCP) that mediates intercellular communication and controls bacterial virulence through interaction with its receptor, RopB. Here, we show that LCP and RopB homologues are present in other Firmicutes. We experimentally validate that LCPs with distinct peptide communication codes act as bacterial intercellular signals and regulate gene expression in Streptococcus salivarius, Streptococcus porcinus, Enterococcus malodoratus and Limosilactobacillus reuteri. Our results indicate that LCPs are more widespread than previously thought, and their characterization may uncover new signaling mechanisms and roles in coordinating diverse bacterial traits.

Suggested Citation

  • Shifu Aggarwal & Elaine Huang & Hackwon Do & Nishanth Makthal & Yanyan Li & Eric Bapteste & Philippe Lopez & Charles Bernard & Muthiah Kumaraswami, 2023. "The leaderless communication peptide (LCP) class of quorum-sensing peptides is broadly distributed among Firmicutes," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41719-3
    DOI: 10.1038/s41467-023-41719-3
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    References listed on IDEAS

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    1. Hackwon Do & Nishanth Makthal & Arica R. VanderWal & Matthew Ojeda Saavedra & Randall J. Olsen & James M. Musser & Muthiah Kumaraswami, 2019. "Environmental pH and peptide signaling control virulence of Streptococcus pyogenes via a quorum-sensing pathway," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
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