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An entropy-controlled objective chip for reflective confocal microscopy with subdiffraction-limit resolution

Author

Listed:
  • Jun He

    (University of Science and Technology of China)

  • Dong Zhao

    (University of Science and Technology of China)

  • Hong Liu

    (Agency for Science Technology and Research (A*STAR), 2 Fusionopolis Way, #08-03, Innovis)

  • Jinghua Teng

    (Agency for Science Technology and Research (A*STAR), 2 Fusionopolis Way, #08-03, Innovis)

  • Cheng-Wei Qiu

    (National University of Singapore)

  • Kun Huang

    (University of Science and Technology of China)

Abstract

Planar diffractive lenses (PDLs) with optimized but disordered structures can focus light beyond the diffraction limit. However, these disordered structures have inevitably destroyed wide-field imaging capability, limiting their applications in microscopy. Here, we introduce information entropy S to evaluate the disorder of an objective chip by using the probability of its structural deviation from standard Fresnel zone plates. Inspired by the theory of entropy change, we predict an equilibrium point $${S}_{0}=0.5$$ S 0 = 0.5 to balance wide-field imaging (theoretically evaluated by the Strehl ratio) and subdiffraction-limit focusing. To verify this, a $${NA}=0.9$$ N A = 0.9 objective chip with a record-long focal length of 1 mm is designed with $$S=0.535$$ S = 0.535 , which is the nearest to the equilibrium point among all reported PDLs. Consequently, our fabricated chip can focus light with subdiffraction-limit size of 0.44 λ and image fine details with spatial frequencies up to 4000 lp/mm experimentally. These unprecedented performances enable ultracompact reflective confocal microscopy for superresolution imaging.

Suggested Citation

  • Jun He & Dong Zhao & Hong Liu & Jinghua Teng & Cheng-Wei Qiu & Kun Huang, 2023. "An entropy-controlled objective chip for reflective confocal microscopy with subdiffraction-limit resolution," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41605-y
    DOI: 10.1038/s41467-023-41605-y
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    References listed on IDEAS

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    1. Kun Huang & Hong Liu & Francisco J. Garcia-Vidal & Minghui Hong & Boris Luk’yanchuk & Jinghua Teng & Cheng-Wei Qiu, 2015. "Ultrahigh-capacity non-periodic photon sieves operating in visible light," Nature Communications, Nature, vol. 6(1), pages 1-7, November.
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