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Dual enzyme-powered chemotactic cross β amyloid based functional nanomotors

Author

Listed:
  • Chandranath Ghosh

    (Indian Institute of Science Education and Research (IISER))

  • Souvik Ghosh

    (Indian Institute of Science Education and Research (IISER))

  • Ayan Chatterjee

    (Indian Institute of Science Education and Research (IISER))

  • Palash Bera

    (Tata Institute of Fundamental Research (TIFR))

  • Dileep Mampallil

    (Indian Institute of Science Education and Research (IISER) Tirupati)

  • Pushpita Ghosh

    (School of Chemistry, Indian Institute of Science Education and Research (IISER))

  • Dibyendu Das

    (Indian Institute of Science Education and Research (IISER))

Abstract

Nanomotor chassis constructed from biological precursors and powered by biocatalytic transformations can offer important applications in the future, specifically in emergent biomedical techniques. Herein, cross β amyloid peptide-based nanomotors (amylobots) were prepared from short amyloid peptides. Owing to their remarkable binding capabilities, these soft constructs are able to host dedicated enzymes to catalyze orthogonal substrates for motility and navigation. Urease helps in powering the self-diffusiophoretic motion, while cytochrome C helps in providing navigation control. Supported by the simulation model, the design principle demonstrates the utilization of two distinct transport behaviours for two different types of enzymes, firstly enhanced diffusivity of urease with increasing fuel (urea) concentration and secondly, chemotactic motility of cytochrome C towards its substrate (pyrogallol). Dual catalytic engines allow the amylobots to be utilized for enhanced catalysis in organic solvent and can thus complement the technological applications of enzymes.

Suggested Citation

  • Chandranath Ghosh & Souvik Ghosh & Ayan Chatterjee & Palash Bera & Dileep Mampallil & Pushpita Ghosh & Dibyendu Das, 2023. "Dual enzyme-powered chemotactic cross β amyloid based functional nanomotors," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41301-x
    DOI: 10.1038/s41467-023-41301-x
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    References listed on IDEAS

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    1. Sui Huang, 2016. "Where to Go: Breaking the Symmetry in Cell Motility," PLOS Biology, Public Library of Science, vol. 14(5), pages 1-10, May.
    2. Xavier Arqué & Adrian Romero-Rivera & Ferran Feixas & Tania Patiño & Sílvia Osuna & Samuel Sánchez, 2019. "Intrinsic enzymatic properties modulate the self-propulsion of micromotors," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
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