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Gabapentinoid consumption in 65 countries and regions from 2008 to 2018: a longitudinal trend study

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Listed:
  • Adrienne Y. L. Chan

    (University of Groningen
    Laboratory of Data Discovery for Health (D24H), Hong Kong Science Park
    The University of Hong Kong
    University College London)

  • Andrew S. C. Yuen

    (University College London
    University College London Hospitals NHS Foundation Trust)

  • Daniel H. T. Tsai

    (St George’s University of London
    National Cheng Kung University)

  • Wallis C. Y. Lau

    (Laboratory of Data Discovery for Health (D24H), Hong Kong Science Park
    The University of Hong Kong
    University College London
    University College London Hospitals NHS Foundation Trust)

  • Yogini H. Jani

    (University College London
    University College London Hospitals NHS Foundation Trust)

  • Yingfen Hsia

    (St George’s University of London
    Queen’s University Belfast)

  • David P. J. Osborn

    (University College London
    Camden and Islington NHS Foundation Trust)

  • Joseph F. Hayes

    (University College London
    Camden and Islington NHS Foundation Trust)

  • Frank M. C. Besag

    (University College London
    East London Foundation NHS Trust)

  • Edward C. C. Lai

    (National Cheng Kung University)

  • Li Wei

    (University College London
    University College London Hospitals NHS Foundation Trust)

  • Katja Taxis

    (University of Groningen)

  • Ian C. K. Wong

    (Laboratory of Data Discovery for Health (D24H), Hong Kong Science Park
    The University of Hong Kong
    University College London
    University College London Hospitals NHS Foundation Trust)

  • Kenneth K. C. Man

    (Laboratory of Data Discovery for Health (D24H), Hong Kong Science Park
    The University of Hong Kong
    University College London
    University College London Hospitals NHS Foundation Trust)

Abstract

Recent studies raised concerns about the increasing use of gabapentinoids in different countries. With their potential for misuse and addiction, understanding the global consumption of gabapentinoids will offer us a platform to examine the need for any interventional policies. This longitudinal trend study utilised pharmaceutical sales data from 65 countries and regions across the world to evaluate the global trends in gabapentinoid consumption between 2008-2018. The multinational average annual percentage change of gabapentinoid consumption was +17.20%, increased from 4.17 defined daily dose per ten thousand inhabitants per day (DDD/TID) in 2008 to 18.26 DDD/TID in 2018. High-income countries had the highest pooled gabapentinoid consumption rate (39.92 DDD/TID) in 2018, which was more than six times higher than the lower-middle income countries (6.11 DDD/TID). The study shows that despite differences in healthcare system and culture, a consistent increase in gabapentinoid consumption is observed worldwide, with high-income countries remaining the largest consumers.

Suggested Citation

  • Adrienne Y. L. Chan & Andrew S. C. Yuen & Daniel H. T. Tsai & Wallis C. Y. Lau & Yogini H. Jani & Yingfen Hsia & David P. J. Osborn & Joseph F. Hayes & Frank M. C. Besag & Edward C. C. Lai & Li Wei & , 2023. "Gabapentinoid consumption in 65 countries and regions from 2008 to 2018: a longitudinal trend study," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40637-8
    DOI: 10.1038/s41467-023-40637-8
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    References listed on IDEAS

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    1. Alyssa M. Peckham & Kathleen A. Fairman & David A. Sclar, 2018. "All-Cause and Drug-Related Medical Events Associated with Overuse of Gabapentin and/or Opioid Medications: A Retrospective Cohort Analysis of a Commercially Insured US Population," Drug Safety, Springer, vol. 41(2), pages 213-228, February.
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