IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-40490-9.html
   My bibliography  Save this article

Self-sampling monkeypox virus testing in high-risk populations, asymptomatic or with unrecognized Mpox, in Spain

Author

Listed:
  • Cristina Agustí

    (Government of Catalonia
    Instituto de Salud Carlos III
    Campus Can Ruti)

  • Héctor Martínez-Riveros

    (Government of Catalonia
    Campus Can Ruti
    Universitat Autònoma de Barcelona)

  • Àgueda Hernández-Rodríguez

    (Germans Trias i Pujol University Hospital
    Autonomous University of Barcelona)

  • Cristina Casañ

    (Germans Trias i Pujol University Hospital)

  • Yesika Díaz

    (Government of Catalonia)

  • Lucía Alonso

    (Government of Catalonia
    Hospital Germans Trias i Pujol)

  • Elisa Martró

    (Instituto de Salud Carlos III
    Campus Can Ruti
    Germans Trias i Pujol University Hospital
    Autonomous University of Barcelona)

  • Jordana Muñoz-Basagoiti

    (Hospital Germans Trias i Pujol)

  • Marçal Gallemí

    (Hospital Germans Trias i Pujol)

  • Cinta Folch

    (Government of Catalonia
    Instituto de Salud Carlos III
    Campus Can Ruti)

  • Ibrahim Sönmez

    (Government of Catalonia
    Campus Can Ruti)

  • Héctor Adell

    (ONG Stop)

  • Marta Villar

    (ONG Stop)

  • Alexia París de León

    (Germans Trias i Pujol University Hospital)

  • Sandra Martinez-Puchol

    (Campus Can Ruti
    Germans Trias i Pujol University Hospital
    Universitat de Barcelona(UB))

  • A. C. Pelegrin

    (Campus Can Ruti
    Germans Trias i Pujol University Hospital)

  • Daniel Perez-Zsolt

    (Hospital Germans Trias i Pujol)

  • Dàlia Raïch-Regué

    (Hospital Germans Trias i Pujol)

  • Rubén Mora

    (ONG Stop)

  • Luis Villegas

    (ONG Stop)

  • Bonaventura Clotet

    (Campus Can Ruti
    Hospital Germans Trias i Pujol
    Hospital Germans Trias i Pujol
    University of Vic–Central University of Catalonia (uVic-UCC))

  • Nuria Izquierdo-Useros

    (Campus Can Ruti
    Hospital Germans Trias i Pujol
    Instituto de Salud Carlos III)

  • Pere-Joan Cardona

    (Germans Trias i Pujol University Hospital
    Autonomous University of Barcelona
    Instituto de Salud Carlos III)

  • Jordi Casabona

    (Government of Catalonia
    Instituto de Salud Carlos III
    Campus Can Ruti
    Autonomous University of Barcelona)

Abstract

The recent monkeypox virus (MPXV) outbreak was of global concern and has mainly affected gay, bisexual and other men who have sex with men (GBMSM). Here we assess prevalence of MPXV in high-risk populations of GBMSM, trans women (TW) and non-binary people without symptoms or with unrecognized monkeypox (Mpox) symptoms, using a self-sampling strategy. Anal and pharyngeal swabs are tested by MPXV real-time PCR and positive samples are tested for cytopathic effect (CPE) in cell culture. 113 individuals participated in the study, 89 (78.76%) were cis men, 17 (15.04%) were TW. The median age was 35.0 years (IQR: 30.0–43.0), 96 (85.02%) individuals were gay or bisexual and 72 (63.72%) were migrants. Seven participants were MPXV positive (6.19% (95% CI: 1.75%–10.64%)). Five tested positive in pharyngeal swabs, one in anal swab and one in both. Six did not present symptoms recognized as MPXV infection. Three samples were positive for CPE, and showed anti-vaccinia pAb staining by FACS and confocal microscopy. This suggests that unrecognized Mpox cases can shed infectious virus. Restricting testing to individuals reporting Mpox symptoms may not be sufficient to contain outbreaks.

Suggested Citation

  • Cristina Agustí & Héctor Martínez-Riveros & Àgueda Hernández-Rodríguez & Cristina Casañ & Yesika Díaz & Lucía Alonso & Elisa Martró & Jordana Muñoz-Basagoiti & Marçal Gallemí & Cinta Folch & Ibrahim S, 2023. "Self-sampling monkeypox virus testing in high-risk populations, asymptomatic or with unrecognized Mpox, in Spain," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40490-9
    DOI: 10.1038/s41467-023-40490-9
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-40490-9
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-023-40490-9?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40490-9. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.