IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-40328-4.html
   My bibliography  Save this article

Practical diagnosis of cirrhosis in non-alcoholic fatty liver disease using currently available non-invasive fibrosis tests

Author

Listed:
  • Jérôme Boursier

    (Angers University Hospital
    Angers University)

  • Marine Roux

    (Angers University)

  • Charlotte Costentin

    (Clinique Universitaire d’Hépato-gastroentérologie, CHU Grenoble Alpes
    CNRS UMR 5309-INSERM U1209)

  • Julien Chaigneau

    (Angers University)

  • Céline Fournier-Poizat

    (Echosens)

  • Aldo Trylesinski

    (AdvanzPharma)

  • Clémence M. Canivet

    (Angers University Hospital
    Angers University)

  • Sophie Michalak

    (Angers University
    Angers University Hospital)

  • Brigitte Bail

    (Bordeaux University Hospital
    INSERM, Université de Bordeaux)

  • Valérie Paradis

    (Beaujon Hospital Paris Diderot University)

  • Pierre Bedossa

    (Beaujon Hospital Paris Diderot University
    Liverpat)

  • Nathalie Sturm

    (CHU Grenoble Alpes)

  • Victor Ledinghen

    (INSERM, Université de Bordeaux
    Bordeaux University Hospital)

  • Philip N. Newsome

    (Birmingham Biomedical Research Centre at University Hospitals Birmingham NHS Foundation Trust
    University of Birmingham
    Liver Unit, University Hospitals Birmingham NHS Foundation Trust)

Abstract

Unlike for advanced liver fibrosis, the practical rules for the early non-invasive diagnosis of cirrhosis in NAFLD remain not well defined. Here, we report the derivation and validation of a stepwise diagnostic algorithm in 1568 patients with NAFLD and liver biopsy coming from four independent cohorts. The study algorithm, using first the elastography-based tests Agile3+ and Agile4 and then the specialized blood tests FibroMeterV3G and CirrhoMeterV3G, provides stratification in four groups, the last of which is enriched in cirrhosis (71% prevalence in the validation set). A risk prediction chart is also derived to allow estimation of the individual probability of cirrhosis. The predicted risk shows excellent calibration in the validation set, and mean difference with perfect prediction is only −2.9%. These tools improve the personalized non-invasive diagnosis of cirrhosis in NAFLD.

Suggested Citation

  • Jérôme Boursier & Marine Roux & Charlotte Costentin & Julien Chaigneau & Céline Fournier-Poizat & Aldo Trylesinski & Clémence M. Canivet & Sophie Michalak & Brigitte Bail & Valérie Paradis & Pierre Be, 2023. "Practical diagnosis of cirrhosis in non-alcoholic fatty liver disease using currently available non-invasive fibrosis tests," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40328-4
    DOI: 10.1038/s41467-023-40328-4
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-40328-4
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-023-40328-4?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Jiahao Gao & Ya Wang & Xianfu Meng & Xiaoshuang Wang & Fang Han & Hao Xing & Guanglei Lv & Li Zhang & Shiman Wu & Xingwu Jiang & Zhenwei Yao & Xiangming Fang & Jiawen Zhang & Wenbo Bu, 2024. "A FAPα-activated MRI nanoprobe for precise grading diagnosis of clinical liver fibrosis," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40328-4. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.