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An osteoinductive and biodegradable intramedullary implant accelerates bone healing and mitigates complications of bone transport in male rats

Author

Listed:
  • Sien Lin

    (Stanford University)

  • Hirotsugu Maekawa

    (Stanford University)

  • Seyedsina Moeinzadeh

    (Stanford University)

  • Elaine Lui

    (Stanford University
    Stanford University)

  • Hossein Vahid Alizadeh

    (Stanford University)

  • Jiannan Li

    (Stanford University)

  • Sungwoo Kim

    (Stanford University)

  • Michael Poland

    (Colorado State University)

  • Benjamin C. Gadomski

    (Colorado State University)

  • Jeremiah T. Easley

    (Colorado State University)

  • Jeffrey Young

    (Stanford University)

  • Michael Gardner

    (Stanford University)

  • David Mohler

    (Stanford University)

  • William J. Maloney

    (Stanford University)

  • Yunzhi Peter Yang

    (Stanford University
    Stanford University
    Stanford University)

Abstract

Bone transport is a surgery-driven procedure for the treatment of large bone defects. However, challenging complications include prolonged consolidation, docking site nonunion and pin tract infection. Here, we develop an osteoinductive and biodegradable intramedullary implant by a hybrid tissue engineering construct technique to enable sustained delivery of bone morphogenetic protein-2 as an adjunctive therapy. In a male rat bone transport model, the eluting bone morphogenetic protein-2 from the implants accelerates bone formation and remodeling, leading to early bony fusion as shown by imaging, mechanical testing, histological analysis, and microarray assays. Moreover, no pin tract infection but tight osseointegration are observed. In contrast, conventional treatments show higher proportion of docking site nonunion and pin tract infection. The findings of this study demonstrate that the novel intramedullary implant holds great promise for advancing bone transport techniques by promoting bone regeneration and reducing complications in the treatment of bone defects.

Suggested Citation

  • Sien Lin & Hirotsugu Maekawa & Seyedsina Moeinzadeh & Elaine Lui & Hossein Vahid Alizadeh & Jiannan Li & Sungwoo Kim & Michael Poland & Benjamin C. Gadomski & Jeremiah T. Easley & Jeffrey Young & Mich, 2023. "An osteoinductive and biodegradable intramedullary implant accelerates bone healing and mitigates complications of bone transport in male rats," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40149-5
    DOI: 10.1038/s41467-023-40149-5
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