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A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs

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  • Jeffrey J. Sutherland

    (Novartis Institutes for Biomedical Research)

  • Dimitar Yonchev

    (Novartis Institutes for Biomedical Research)

  • Alexander Fekete

    (Novartis Institutes for Biomedical Research)

  • Laszlo Urban

    (Novartis Institutes for Biomedical Research)

Abstract

In vitro secondary pharmacology assays are an important tool for predicting clinical adverse drug reactions (ADRs) of investigational drugs. We created the Secondary Pharmacology Database (SPD) by testing 1958 drugs using 200 assays to validate target-ADR associations. Compared to public and subscription resources, 95% of all and 36% of active (AC50

Suggested Citation

  • Jeffrey J. Sutherland & Dimitar Yonchev & Alexander Fekete & Laszlo Urban, 2023. "A preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40064-9
    DOI: 10.1038/s41467-023-40064-9
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